https://scholars.lib.ntu.edu.tw/handle/123456789/626907
標題: | Dysregulated affective arousal regulates reward-based decision making in patients with schizophrenia: an integrated study | 作者: | Liu, Hong-Hsiang CHIH-MIN LIU MING-HSIEN HSIEH YI-LING CHIEN Hsu, Yung-Fong Lai, Wen-Sung |
關鍵字: | EVENT-RELATED POTENTIALS; NEGATIVE SYNDROME SCALE; FACIAL EXPRESSION; EMOTION AWARENESS; TIME-COURSE; LOSE-SHIFT; WIN-STAY; PREDICTION; ERROR; INDIVIDUALS | 公開日期: | 21-三月-2022 | 出版社: | NATURE PORTFOLIO | 卷: | 8 | 期: | 1 | 來源出版物: | Schizophrenia (Heidelberg, Germany) | 摘要: | Schizophrenia is a chronic and severe mental disorder. Dysregulated decision-making and affective processing have been implicated in patients with schizophrenia (SZ) and have significant impacts on their cognitive and social functions. However, little is known about how affective arousal influences reward-based decision-making in SZ. Taking advantage of a two-choice probabilistic gambling task and utilizing three facial expressions as affective primes (i.e., neutral, angry, and happy conditions) in each trial, we investigated how affective arousal influences reward-related choice based on behavioral, model fitting, and feedback-related negativity (FRN) data in 38 SZ and 26 healthy controls (CTRL). We also correlated our measurements with patients' symptom severity. Compared with the CTRL group, SZ expressed blunted responses to angry facial primes. They had lower total game scores and displayed more maladaptive choice strategies (i.e., less win-stay and more lose-shift) and errors in monitoring rewards. Model fitting results revealed that the SZ group had a higher learning rate and lower choice consistency, especially in the happy condition. Brain activity data further indicated that SZ had smaller amplitudes of FRN than their controls in the angry and happy conditions. Importantly, the SZ group exhibited attenuated affective influence on decision-making, and their impairments in decision-making were only correlated with their clinical symptoms in the angry condition. Our findings imply the affective processing is dysregulated in SZ and it is selectively involved in the regulation of choice strategies, choice behaviors, and FRN in SZ, which lead to impairments in reward-related decision-making, especially in the angry condition. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/626907 | ISSN: | 2754-6993 | DOI: | 10.1038/s41537-022-00234-y |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。