https://scholars.lib.ntu.edu.tw/handle/123456789/626999
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Castaño, Ana P | en_US |
dc.contributor.author | SHUEI-LIONG LIN | en_US |
dc.contributor.author | Surowy, Teresa | en_US |
dc.contributor.author | Nowlin, Brian T | en_US |
dc.contributor.author | Turlapati, Swathi A | en_US |
dc.contributor.author | Patel, Tejas | en_US |
dc.contributor.author | Singh, Ajay | en_US |
dc.contributor.author | Li, Shawn | en_US |
dc.contributor.author | Lupher, Mark L | en_US |
dc.contributor.author | Duffield, Jeremy S | en_US |
dc.date.accessioned | 2023-01-07T04:56:29Z | - |
dc.date.available | 2023-01-07T04:56:29Z | - |
dc.date.issued | 2009-11-04 | - |
dc.identifier.issn | 1946-6234 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/626999 | - |
dc.description.abstract | New therapies that target chronic inflammation with fibrosis are urgently required. Increasing evidence points to innate activation of inflammatory cells in driving chronic organ fibrosis. Serum amyloid P is a naturally circulating soluble pattern recognition receptor, a member of the family of pentraxin proteins. It links danger-associated molecular pattern recognition to Fc gamma receptor-mediated phagocytosis. Here we show that fibrosis progression in the mouse kidney is significantly inhibited by therapeutic administration of human serum amyloid P, regulated by activating Fc gamma receptors, and dependent on inflammatory monocytes and macrophages, but not fibrocytes. Human serum amyloid P-mediated inhibition of mouse kidney fibrosis correlated with specific binding of human serum amyloid P to cell debris and with subsequent suppression of inflammatory monocytes and kidney macrophages in vitro and in vivo, and was dependent on regulated binding to activating Fc gamma receptors and interleukin-10 expression. These studies uncover previously unidentified roles for Fc gamma receptors in sterile inflammation and highlight serum amyloid P as a potential antifibrotic therapy through local generation of interleukin-10. | en_US |
dc.language.iso | en | en_US |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | en_US |
dc.relation.ispartof | Science translational medicine | en_US |
dc.subject | C-REACTIVE PROTEIN; EPITHELIAL-CELLS; APOPTOTIC CELLS; INNATE IMMUNITY; DEFICIENT MICE; KIDNEY INJURY; COMPONENT; PENTRAXINS; DIFFERENTIATION; PHAGOCYTOSIS | en_US |
dc.title | Serum amyloid P inhibits fibrosis through Fc gamma R-dependent monocyte-macrophage regulation in vivo | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1126/scitranslmed.3000111 | - |
dc.identifier.pmid | 20368175 | - |
dc.identifier.scopus | 2-s2.0-77749319814 | - |
dc.identifier.isi | WOS:000277197300001 | - |
dc.identifier.url | https://scholars.lib.ntu.edu.tw/handle/123456789/540371 | - |
dc.relation.journalvolume | 1 | en_US |
dc.relation.journalissue | 5 | en_US |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Physiology | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Integrated Diagnostics and Therapeutics-NTUH | - |
crisitem.author.orcid | 0000-0002-1041-5571 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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