https://scholars.lib.ntu.edu.tw/handle/123456789/627436
Title: | Intravenous calcitriol treatment benefits the homeostasis of CD4+ T cells and attenuates kidney injury in obese mice complicated with polymicrobial sepsis | Authors: | Yeh, Chiu-Li JIN-MING WU PO-JEN YANG PO-CHU LEE KUEN-YUAN CHEN Yeh, Sung-Ling MING-TSAN LIN |
Keywords: | Kidney injury markers; M1 macrophage; M2 macrophage; Regulatory T cells; T-helper cells; Th17:Treg ratio | Issue Date: | 2022 | Publisher: | ELSEVIER SCIENCE INC | Journal Volume: | 103-104 | Source: | Nutrition | Abstract: | Sepsis is a lethal clinical condition with dysregulated cluster of differentiation (CD) 4+ T cells that leads to inflammation and multiorgan injury. Low vitamin D levels are commonly seen in patients with sepsis. Obesity is a state with oxidative stress and chronic inflammation. Both obesity and low vitamin D levels are associated with adverse outcomes in patients with sepsis. This study investigated the effects of calcitriol on CD4+ T-cell polarization and kidney injury during sepsis. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/627436 | ISSN: | 0899-9007 | DOI: | 10.1016/j.nut.2022.111741 |
Appears in Collections: | 醫學系 |
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