https://scholars.lib.ntu.edu.tw/handle/123456789/627578
標題: | Amelioration of Maternal Immune Activation-Induced Autism Relevant Behaviors by Gut Commensal Parabacteroides goldsteinii | 作者: | Lin, Tzu-Lung Lu, Cha-Chen Chen, Ting-Wen Huang, Chih-Wei Lu, Jang-Jih Lai, Wei-Fan Wu, Ting-Shu Lai, Chih-Ho HSIN-CHIH LAI Chen, Ya-Lei |
關鍵字: | Parabacteroides goldsteinii; autism spectrum disorders; lipopolysaccharides; maternal immune activation; next-generation probiotic | 公開日期: | 28-十月-2022 | 出版社: | MDPI | 卷: | 23 | 期: | 21 | 來源出版物: | International journal of molecular sciences | 摘要: | Autism spectrum disorder (ASD) is characterized by cognitive inflexibility and social deficits. Probiotics have been demonstrated to play a promising role in managing the severity of ASD. However, there are no effective probiotics for clinical use. Identifying new probiotic strains for ameliorating ASD is therefore essential. Using the maternal immune activation (MIA)-based offspring ASD-like mouse model, a probiotic-based intervention strategy was examined in female mice. The gut commensal microbe Parabacteroides goldsteinii MTS01, which was previously demonstrated to exert multiple beneficial effects on chronic inflammation-related-diseases, was evaluated. Prenatal lipopolysaccharide (LPS) exposure induced leaky gut-related inflammatory phenotypes in the colon, increased LPS activity in sera, and induced autistic-like behaviors in offspring mice. By contrast, P. goldsteinii MTS01 treatment significantly reduced intestinal and systemic inflammation and ameliorated disease development. Transcriptomic analyses of MIA offspring indicated that in the intestine, P. goldsteinii MTS01 enhanced neuropeptide-related signaling and suppressed aberrant cell proliferation and inflammatory responses. In the hippocampus, P. goldsteinii MTS01 increased ribosomal/mitochondrial and antioxidant activities and decreased glutamate receptor signaling. Together, significant ameliorative effects of P. goldsteinii MTS01 on ASD relevant behaviors in MIA offspring were identified. Therefore, P. goldsteinii MTS01 could be developed as a next-generation probiotic for ameliorating ASD. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/627578 | ISSN: | 16616596 | DOI: | 10.3390/ijms232113070 |
顯示於: | 醫學檢驗暨生物技術學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。