https://scholars.lib.ntu.edu.tw/handle/123456789/627640
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Weng, Meng-Tzu | en_US |
dc.contributor.author | Yang, Shih-Feng | en_US |
dc.contributor.author | Liu, Shin-Yun | en_US |
dc.contributor.author | Hsu, Yu-Chen | en_US |
dc.contributor.author | Wu, Meng-Chuan | en_US |
dc.contributor.author | Chou, Huei-Chi | en_US |
dc.contributor.author | Chiou, Ling-Ling | en_US |
dc.contributor.author | JA-DER LIANG | en_US |
dc.contributor.author | Wang, Li-Fang | en_US |
dc.contributor.author | Lee, Hsuan-Shu | en_US |
dc.contributor.author | Sheu, Jin-Chuan | en_US |
dc.date.accessioned | 2023-02-06T03:16:09Z | - |
dc.date.available | 2023-02-06T03:16:09Z | - |
dc.date.issued | 2023-01-05 | - |
dc.identifier.issn | 10436618 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/627640 | - |
dc.description.abstract | The efficacy of treatment for advanced hepatocellular carcinoma (HCC) has remained limited. Polyinosinic-polycytidylic acid-poly-L-lysine carboxymethylcellulose (poly-ICLC) is a synthetic double-stranded RNA that serves as a viral mimic and induces an immune response. Intratumoral (IT) poly-ICLC injections can induce an autovaccination effect and prime the immune system, whereas intramuscular (IM) injection of poly-ICLC can attract and maintain tumor-specific cytotoxic T lymphocytes in tumors. We found that IT injection of poly-ICLC upregulated the expression of CD83 and CD86 on conventional type 1 dendritic cells in tumors. Combination therapy with IT followed by IM injections of poly-ICLC significantly inhibited tumor growth and increased the tumor-infiltrating CD8+ T cells in two syngeneic mouse models of HCC. Depletion of CD8+ T cells attenuated the antitumor effect. An IFN-γ enzyme-linked immunospot of purified tumoral CD8+ T cells revealed a significant proportion of tumor-specific T cells. Finally, the sequential poly-ICLC therapy induced abscopal effects in two dual-tumor models. This study provides evidence that the sequential poly-ICLC therapy significantly increased infiltration of tumor-specific CD8+ T cells in the tumors and induced CD8+ T cell-dependent inhibition of tumor growth, as well as abscopal effects. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Pharmacological research | en_US |
dc.subject | Abscopal effect; Hepatocellular carcinoma; Poly-ICLC; in situ vaccination | en_US |
dc.title | In situ vaccination followed by intramuscular poly-ICLC injections for the treatment of hepatocellular carcinoma in mouse models | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.phrs.2023.106646 | - |
dc.identifier.pmid | 36621619 | - |
dc.identifier.scopus | 2-s2.0-85146574853 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85146574853 | - |
dc.relation.pages | 106646 | en_US |
dc.relation.journalvolume | 188 | en_US |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Biotechnology | - |
crisitem.author.orcid | 0000-0002-4532-0118 | - |
crisitem.author.orcid | 0000-0002-8017-0434 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
顯示於: | 醫學系 |
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