https://scholars.lib.ntu.edu.tw/handle/123456789/627675
標題: | Acetylation of yeast AMPK controls intrinsic aging independently of caloric restriction | 作者: | JIN-YING LU Lin, Yu-Yi JIN-CHUAN SHEU Wu, June-Tai FANG-JEN LEE Chen, Yue Lin, Min-I FU-TIEN CHIANG TONG-YUAN TAI Berger, Shelley L Zhao, Yingming KEH-SUNG TSAI Zhu, Heng LEE-MING CHUANG Boeke, Jef D |
關鍵字: | SNF1 PROTEIN-KINASE; SACCHAROMYCES-CEREVISIAE; LIFE-SPAN; CAENORHABDITIS-ELEGANS; SCH9; SENESCENCE; EXTENSION; LONGEVITY; TARGET; STRESS | 公開日期: | 16-九月-2011 | 出版社: | CELL PRESS | 卷: | 146 | 期: | 6 | 起(迄)頁: | 968 | 來源出版物: | Cell | 摘要: | Acetylation of histone and nonhistone proteins is an important posttranslational modification affecting many cellular processes. Here, we report that NuA4 acetylation of Sip2, a regulatory β subunit of the Snf1 complex (yeast AMP-activated protein kinase), decreases as cells age. Sip2 acetylation, controlled by antagonizing NuA4 acetyltransferase and Rpd3 deacetylase, enhances interaction with Snf1, the catalytic subunit of Snf1 complex. Sip2-Snf1 interaction inhibits Snf1 activity, thus decreasing phosphorylation of a downstream target, Sch9 (homolog of Akt/S6K), and ultimately leading to slower growth but extended replicative life span. Sip2 acetylation mimetics are more resistant to oxidative stress. We further demonstrate that the anti-aging effect of Sip2 acetylation is independent of extrinsic nutrient availability and TORC1 activity. We propose a protein acetylation-phosphorylation cascade that regulates Sch9 activity, controls intrinsic aging, and extends replicative life span in yeast. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/627675 | ISSN: | 0092-8674 | DOI: | 10.1016/j.cell.2011.07.044 |
顯示於: | 醫學系 |
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