標題: | Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility |
作者: | Mahajan, Anubha Go, Min Jin Zhang, Weihua Below, Jennifer E Gaulton, Kyle J Ferreira, Teresa Horikoshi, Momoko Johnson, Andrew D Ng, Maggie C Y Prokopenko, Inga Saleheen, Danish Wang, Xu Zeggini, Eleftheria Abecasis, Goncalo R Adair, Linda S Almgren, Peter Atalay, Mustafa Aung, Tin Baldassarre, Damiano Balkau, Beverley Bao, Yuqian Barnett, Anthony H Barroso, Ines Basit, Abdul Been, Latonya F Beilby, John Bell, Graeme I Benediktsson, Rafn Bergman, Richard N Boehm, Bernhard O Boerwinkle, Eric Bonnycastle, Lori L Burtt, Noël Cai, Qiuyin Campbell, Harry Carey, Jason Cauchi, Stephane Caulfield, Mark Chan, Juliana C N Chang, Li-Ching TIEN-JYUN CHANG YI-CHENG CHANG Charpentier, Guillaume Chen, Chien-Hsiun Chen, Han Chen, Yuan-Tsong Chia, Kee-Seng Chidambaram, Manickam Chines, Peter S Cho, Nam H Cho, Young Min LEE-MING CHUANG Collins, Francis S Cornelis, Marylin C Couper, David J Crenshaw, Andrew T van Dam, Rob M Danesh, John Das, Debashish de Faire, Ulf Dedoussis, George Deloukas, Panos Dimas, Antigone S Dina, Christian Doney, Alex S Donnelly, Peter J Dorkhan, Mozhgan van Duijn, Cornelia Dupuis, Josée Edkins, Sarah Elliott, Paul Emilsson, Valur Erbel, Raimund Eriksson, Johan G Escobedo, Jorge Esko, Tonu Eury, Elodie Florez, Jose C Fontanillas, Pierre Forouhi, Nita G Forsen, Tom Fox, Caroline Fraser, Ross M Frayling, Timothy M Froguel, Philippe Frossard, Philippe Gao, Yutang Gertow, Karl Gieger, Christian Gigante, Bruna Grallert, Harald Grant, George B Grrop, Leif C Groves, Chrisropher J Grundberg, Elin Guiducci, Candace Hamsten, Anders Han, Bok-Ghee Hara, Kazuo Hassanali, Neelam Hattersley, Andrew T Hayward, Caroline Hedman, Asa K Herder, Christian Hofman, Albert Holmen, Oddgeir L Hovingh, Kees Hreidarsson, Astradur B Hu, Cheng Hu, Frank B Hui, Jennie Humphries, Steve E Hunt, Sarah E Hunter, David J Hveem, Kristian Hydrie, Zafar I Ikegami, Hiroshi Illig, Thomas Ingelsson, Erik Islam, Muhammed Isomaa, Bo Jackson, Anne U Jafar, Tazeen James, Alan Jia, Weiping Jöckel, Karl-Heinz Jonsson, Anna Jowett, Jeremy B M Kadowaki, Takashi Kang, Hyun Min Kanoni, Stavroula Kao, Wen Hong L Kathiresan, Sekar Kato, Norihiro Katulanda, Prasad Keinanen-Kiukaanniemi, Kirkka M Kelly, Ann M Khan, Hassan Khaw, Kay-Tee Khor, Chiea-Chuen Kim, Hyung-Lae Kim, Sangsoo Kim, Young Jin Kinnunen, Leena Klopp, Norman Kong, Augustine Korpi-Hyövälti, Eeva Kowlessur, Sudhir Kraft, Peter Kravic, Jasmina Kristensen, Malene M Krithika, S Kumar, Ashish Kumate, Jesus Kuusisto, Johanna Kwak, Soo Heon Laakso, Markku Lagou, Vasiliki Lakka, Timo A Langenberg, Claudia Langford, Cordelia Lawrence, Robert Leander, Karin Lee, Jen-Mai Lee, Nanette R Li, Man Li, Xinzhong Li, Yun Liang, Junbin Liju, Samuel Lim, Wei-Yen Lind, Lars Lindgren, Cecilia M Lindholm, Eero Liu, Ching-Ti Liu, Jian Jun Lobbens, Stéphane Long, Jirong Loos, Ruth J F Lu, Wei Luan, Jian'an Lyssenko, Valeriya Ma, Ronald C W Maeda, Shiro Mägi, Reedik Männisto, Satu Matthews, David R Meigs, James B Melander, Olle Metspalu, Andres Meyer, Julia Mirza, Ghazala Mihailov, Evelin Moebus, Susanne Mohan, Viswanathan Mohlke, Karen L Morris, Andrew D Mühleisen, Thomas W Müller-Nurasyid, Martina Musk, Bill Nakamura, Jiro Nakashima, Eitaro Navarro, Pau Ng, Peng-Keat Nica, Alexandra C Nilsson, Peter M Njølstad, Inger Nöthen, Markus M Ohnaka, Keizo Ong, Twee Hee Owen, Katharine R Palmer, Colin N A Pankow, James S Park, Kyong Soo Parkin, Melissa Pechlivanis, Sonali Pedersen, Nancy L Peltonen, Leena Perry, John R B Peters, Annette Pinidiyapathirage, Janini M Platou, Carl G Potter, Simon Price, Jackie F Qi, Lu Radha, Venkatesan Rallidis, Loukianos Rasheed, Asif Rathman, Wolfgang Rauramaa, Rainer Raychaudhuri, Soumya Rayner, N William Rees, Simon D Rehnberg, Emil Ripatti, Samuli Robertson, Neil Roden, Michael Rossin, Elizabeth J Rudan, Igor Rybin, Denis Saaristo, Timo E Salomaa, Veikko Saltevo, Juha Samuel, Maria Sanghera, Dharambir K Saramies, Jouko Scott, James Scott, Laura J Scott, Robert A Segrè, Ayellet V Sehmi, Joban Sennblad, Bengt Shah, Nabi Shah, Sonia Shera, A Samad Shu, Xiao Ou Shuldiner, Alan R Sigurđsson, Gunnar Sijbrands, Eric Silveira, Angela Sim, Xueling Sivapalaratnam, Suthesh Small, Kerrin S So, Wing Yee Stančáková, Alena Stefansson, Kari Steinbach, Gerald Steinthorsdottir, Valgerdur Stirrups, Kathleen Strawbridge, Rona J Stringham, Heather M Sun, Qi Suo, Chen Syvänen, Ann-Christine Takayanagi, Ryoichi Takeuchi, Fumihiko Tay, Wan Ting Teslovich, Tanya M Thorand, Barbara Thorleifsson, Gudmar Thorsteinsdottir, Unnur Tikkanen, Emmi Trakalo, Joseph Tremoli, Elena Trip, Mieke D Tsai, Fuu Jen Tuomi, Tiinamaija Tuomilehto, Jaakko Uitterlinden, Andre G Valladares-Salgado, Adan Vedantam, Sailaja Veglia, Fabrizio Voight, Benjamin F Wang, Congrong Wareham, Nicholas J Wennauer, Roman Wickremasinghe, Ananda R Wilsgaard, Tom Wilson, James F Wiltshire, Steven Winckler, Wendy Wong, Tien Yin Wood, Andrew R Wu, Jer-Yuarn Wu, Ying Yamamoto, Ken Yamauchi, Toshimasa Yang, Mingyu Yengo, Loic Yokota, Mitsuhiro Young, Robin Zabaneh, Delilah Zhang, Fan Zhang, Rong Zheng, Wei Zimmet, Paul Z Altshuler, David Bowden, Donald W Cho, Yoon Shin Cox, Nancy J Cruz, Miguel Hanis, Craig L Kooner, Jaspal Lee, Jong-Young Seielstad, Mark Teo, Yik Ying Boehnke, Michael Parra, Esteban J Chambers, Jonh C Tai, E Shyong McCarthy, Mark I Morris, Andrew P |
關鍵字: | ASSOCIATION ANALYSES; GLUCOSE-HOMEOSTASIS; LOCI; VARIANTS; INDIVIDUALS; CHROMATIN; IDENTIFY |
公開日期: | 三月-2014 |
出版社: | NATURE PUBLISHING GROUP |
卷: | 46 |
期: | 3 |
起(迄)頁: | 234 |
來源出版物: | Nature genetics |
摘要: | To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signals of association from the trans-ethnic meta-analysis in an additional 21,491 cases and 55,647 controls of European ancestry, we identified seven new T2D susceptibility loci. Furthermore, we observed considerable improvements in the fine-mapping resolution of common variant association signals at several T2D susceptibility loci. These observations highlight the benefits of trans-ethnic GWAS for the discovery and characterization of complex trait loci and emphasize an exciting opportunity to extend insight into the genetic architecture and pathogenesis of human diseases across populations of diverse ancestry. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/627702 |
ISSN: | 1061-4036 |
DOI: | 10.1038/ng.2897 |
顯示於: | 醫學系
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