https://scholars.lib.ntu.edu.tw/handle/123456789/627707
標題: | Genetic variation in the NOC gene is associated with body mass index in Chinese subjects | 作者: | YI-CHENG CHANG Chiu, Yen-Feng Liu, Pi-Hua Hee, Siow Wei TIEN-JYUN CHANG YI-DER JIANG Lee, Wei-Jei PO-CHU LEE Kao, Hui-Yi JUEY-JEN HWANG LEE-MING CHUANG |
關鍵字: | METABOLIC SYNDROME; CIRCADIAN-RHYTHMS; GLUCOSE SENSOR; CLOCK GENE; NOCTURNIN; OBESITY; SUSCEPTIBILITY; POLYMORPHISMS; ADIPOGENESIS; RESISTANCE | 公開日期: | 2013 | 出版社: | PUBLIC LIBRARY SCIENCE | 卷: | 8 | 期: | 7 | 來源出版物: | PloS one | 摘要: | Circadian clock genes are critical regulators of energy homeostasis and metabolism. However, whether variation in the circadian genes is associated with metabolic phenotypes in humans remains to be explored. In this study, we systemically genotyped 20 tag single nucleotide polymorphisms (SNPs) in 8 candidate genes involved in circadian clock, including CLOCK, BMAL1(ARNTL), PER1, PER2, CRY1, CRY2, CSNK1E,, and NOC(CCRN4L) in 1,510 non-diabetic Chinese subjects in Taipei and Yunlin populations in Taiwan. Their associations with metabolic phenotypes were analyzed. We found that genetic variation in the NOC gene, rs9684900 was associated with body mass index (BMI) (P = 0.0016, Bonferroni corrected P = 0.032). Another variant, rs135764 in the CSNK1E gene was associated with fasting glucose (P = 0.0023, Bonferroni corrected P = 0.046). These associations were consistent in both Taipei and Yunlin populations. Significant epistatic and joint effects between SNPs on BMI and related phenotypes were observed. Furthermore, NOC mRNA levels in human abdominal adipose tissue were significantly increased in obese subjects compared to non-obese controls. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/627707 | ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0069622 |
顯示於: | 醫學系 |
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