https://scholars.lib.ntu.edu.tw/handle/123456789/627718
標題: | Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians | 作者: | Cho, Yoon Shin Chen, Chien-Hsiun Hu, Cheng Long, Jirong Ong, Rick Twee Hee Sim, Xueling Takeuchi, Fumihiko Wu, Ying Go, Min Jin Yamauchi, Toshimasa YI-CHENG CHANG Kwak, Soo Heon Ma, Ronald C W Yamamoto, Ken Adair, Linda S Aung, Tin Cai, Qiuyin Chang, Li-Ching Chen, Yuan-Tsong Gao, Yutang Hu, Frank B Kim, Hyung-Lae Kim, Sangsoo Kim, Young Jin Lee, Jeannette Jen-Mai Lee, Nanette R Li, Yun Liu, Jian Jun Lu, Wei Nakamura, Jiro Nakashima, Eitaro Ng, Daniel Peng-Keat Tay, Wan Ting Tsai, Fuu-Jen Wong, Tien Yin Yokota, Mitsuhiro Zheng, Wei Zhang, Rong Wang, Congrong So, Wing Yee Ohnaka, Keizo Ikegami, Hiroshi Hara, Kazuo Cho, Young Min Cho, Nam H TIEN-JYUN CHANG Bao, Yuqian Hedman, Åsa K Morris, Andrew P McCarthy, Mark I Takayanagi, Ryoichi Park, Kyong Soo Jia, Weiping LEE-MING CHUANG Chan, Juliana C N Maeda, Shiro Kadowaki, Takashi Lee, Jong-Young Wu, Jer-Yuarn Teo, Yik Ying Tai, E Shyong Shu, Xiao Ou Mohlke, Karen L Kato, Norihiro Han, Bok-Ghee Seielstad, Mark |
關鍵字: | SUSCEPTIBILITY LOCI; JAPANESE POPULATION; GENETIC-LOCI; VARIANTS; RISK; CHILDHOOD; MELLITUS; COMPLEX; KCNQ1 | 公開日期: | 2012 | 出版社: | NATURE PUBLISHING GROUP | 卷: | 44 | 期: | 1 | 起(迄)頁: | 67 | 來源出版物: | Nature genetics | 摘要: | We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in east Asian populations. We followed our stage 1 meta-analysis of eight T2D genome-wide association studies (6,952 cases with T2D and 11,865 controls) with a stage 2 in silico replication analysis (5,843 cases and 4,574 controls) and a stage 3 de novo replication analysis (12,284 cases and 13,172 controls). The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3. GLIS3, which is involved in pancreatic beta cell development and insulin gene expression, is known for its association with fasting glucose levels. The evidence of an association with T2D for PEPD and HNF4A has been shown in previous studies. KCNK16 may regulate glucose-dependent insulin secretion in the pancreas. These findings, derived from an east Asian population, provide new perspectives on the etiology of T2D. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/627718 | ISSN: | 1061-4036 | DOI: | 10.1038/ng.1019 |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。