https://scholars.lib.ntu.edu.tw/handle/123456789/627718
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Cho, Yoon Shin | en_US |
dc.contributor.author | Chen, Chien-Hsiun | en_US |
dc.contributor.author | Hu, Cheng | en_US |
dc.contributor.author | Long, Jirong | en_US |
dc.contributor.author | Ong, Rick Twee Hee | en_US |
dc.contributor.author | Sim, Xueling | en_US |
dc.contributor.author | Takeuchi, Fumihiko | en_US |
dc.contributor.author | Wu, Ying | en_US |
dc.contributor.author | Go, Min Jin | en_US |
dc.contributor.author | Yamauchi, Toshimasa | en_US |
dc.contributor.author | YI-CHENG CHANG | en_US |
dc.contributor.author | Kwak, Soo Heon | en_US |
dc.contributor.author | Ma, Ronald C W | en_US |
dc.contributor.author | Yamamoto, Ken | en_US |
dc.contributor.author | Adair, Linda S | en_US |
dc.contributor.author | Aung, Tin | en_US |
dc.contributor.author | Cai, Qiuyin | en_US |
dc.contributor.author | Chang, Li-Ching | en_US |
dc.contributor.author | Chen, Yuan-Tsong | en_US |
dc.contributor.author | Gao, Yutang | en_US |
dc.contributor.author | Hu, Frank B | en_US |
dc.contributor.author | Kim, Hyung-Lae | en_US |
dc.contributor.author | Kim, Sangsoo | en_US |
dc.contributor.author | Kim, Young Jin | en_US |
dc.contributor.author | Lee, Jeannette Jen-Mai | en_US |
dc.contributor.author | Lee, Nanette R | en_US |
dc.contributor.author | Li, Yun | en_US |
dc.contributor.author | Liu, Jian Jun | en_US |
dc.contributor.author | Lu, Wei | en_US |
dc.contributor.author | Nakamura, Jiro | en_US |
dc.contributor.author | Nakashima, Eitaro | en_US |
dc.contributor.author | Ng, Daniel Peng-Keat | en_US |
dc.contributor.author | Tay, Wan Ting | en_US |
dc.contributor.author | Tsai, Fuu-Jen | en_US |
dc.contributor.author | Wong, Tien Yin | en_US |
dc.contributor.author | Yokota, Mitsuhiro | en_US |
dc.contributor.author | Zheng, Wei | en_US |
dc.contributor.author | Zhang, Rong | en_US |
dc.contributor.author | Wang, Congrong | en_US |
dc.contributor.author | So, Wing Yee | en_US |
dc.contributor.author | Ohnaka, Keizo | en_US |
dc.contributor.author | Ikegami, Hiroshi | en_US |
dc.contributor.author | Hara, Kazuo | en_US |
dc.contributor.author | Cho, Young Min | en_US |
dc.contributor.author | Cho, Nam H | en_US |
dc.contributor.author | TIEN-JYUN CHANG | en_US |
dc.contributor.author | Bao, Yuqian | en_US |
dc.contributor.author | Hedman, Åsa K | en_US |
dc.contributor.author | Morris, Andrew P | en_US |
dc.contributor.author | McCarthy, Mark I | en_US |
dc.contributor.author | Takayanagi, Ryoichi | en_US |
dc.contributor.author | Park, Kyong Soo | en_US |
dc.contributor.author | Jia, Weiping | en_US |
dc.contributor.author | LEE-MING CHUANG | en_US |
dc.contributor.author | Chan, Juliana C N | en_US |
dc.contributor.author | Maeda, Shiro | en_US |
dc.contributor.author | Kadowaki, Takashi | en_US |
dc.contributor.author | Lee, Jong-Young | en_US |
dc.contributor.author | Wu, Jer-Yuarn | en_US |
dc.contributor.author | Teo, Yik Ying | en_US |
dc.contributor.author | Tai, E Shyong | en_US |
dc.contributor.author | Shu, Xiao Ou | en_US |
dc.contributor.author | Mohlke, Karen L | en_US |
dc.contributor.author | Kato, Norihiro | en_US |
dc.contributor.author | Han, Bok-Ghee | en_US |
dc.contributor.author | Seielstad, Mark | en_US |
dc.date.accessioned | 2023-02-08T02:45:15Z | - |
dc.date.available | 2023-02-08T02:45:15Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1061-4036 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/627718 | - |
dc.description.abstract | We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in east Asian populations. We followed our stage 1 meta-analysis of eight T2D genome-wide association studies (6,952 cases with T2D and 11,865 controls) with a stage 2 in silico replication analysis (5,843 cases and 4,574 controls) and a stage 3 de novo replication analysis (12,284 cases and 13,172 controls). The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3. GLIS3, which is involved in pancreatic beta cell development and insulin gene expression, is known for its association with fasting glucose levels. The evidence of an association with T2D for PEPD and HNF4A has been shown in previous studies. KCNK16 may regulate glucose-dependent insulin secretion in the pancreas. These findings, derived from an east Asian population, provide new perspectives on the etiology of T2D. | en_US |
dc.language.iso | en | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.relation.ispartof | Nature genetics | en_US |
dc.subject | SUSCEPTIBILITY LOCI; JAPANESE POPULATION; GENETIC-LOCI; VARIANTS; RISK; CHILDHOOD; MELLITUS; COMPLEX; KCNQ1 | en_US |
dc.title | Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/ng.1019 | - |
dc.identifier.pmid | 22158537 | - |
dc.identifier.scopus | 2-s2.0-84655162045 | - |
dc.identifier.isi | WOS:000298664000016 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84655162045 | - |
dc.relation.pages | 67 | en_US |
dc.relation.journalvolume | 44 | en_US |
dc.relation.journalissue | 1 | en_US |
dc.relation.pageend | 72 | en_US |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Medical Genomics and Proteomics | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-8077-5011 | - |
crisitem.author.orcid | 0000-0001-9437-5847 | - |
crisitem.author.orcid | 0000-0003-0978-2662 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。