https://scholars.lib.ntu.edu.tw/handle/123456789/627952
標題: | A brief on new waves of monkeypox and vaccines and antiviral drugs for monkeypox | 作者: | Hung, Yuan-Pin Lee, Ching-Chi Lee, Jen-Chieh Chiu, Chun-Wei PO-REN HSUEH Ko, Wen-Chien |
關鍵字: | ACAM2000; Brincidofovir; Jynneostm; Monkeypox; Smallpox; Tecovirimat | 公開日期: | 十月-2022 | 卷: | 55 | 期: | 5 | 來源出版物: | Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi | 摘要: | Monkeypox virus (MPXV), genetic closely linked to the notorious variola (smallpox) virus, currently causes several clusters and outbreaks in the areas outside Africa and is noted to be phylogenetically related to the West African clade. To prepare for the upsurge of the cases of monkeypox in the Europe and North America, two vaccines, Jynneos® in the U.S. (Imvamune® in Canada or Imvanex® in the Europe) and ACAM2000® (Acambis, Inc.) initially developed in the smallpox eradication program, can provide protective immunity to monkeypox, and their production and availability are rapidly scaled up in the response to the emerging threat. So far, these two vaccines are recommended for people at a high risk for monkeypox, instead of universal vaccination. Tecovirimat, an inhibitor of extracellular virus formation, and brincidofovir, a lipid conjugate of cidofovir, both are in vitro and in vivo active against MPXV, and are suggested for immunocompromised persons, who are at risk to develop severe diseases. However, current general consensus in the response to the monkeypox outbreak among public health systems is early identification and isolation of infected patients to prevent its spread. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/627952 | ISSN: | 16841182 | DOI: | 10.1016/j.jmii.2022.08.016 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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