https://scholars.lib.ntu.edu.tw/handle/123456789/627957
標題: | Diabetes mellitus is associated with more adverse non-hemodynamic left ventricular remodeling and less recovery in patients with primary aldosteronism | 作者: | Chen, Uei-Lin CHE-WEI LIAO SHUO-MENG WANG TAI-SHUAN LAI KUO-HOW HUANG CHIN-CHEN CHANG BO-CHING LEE CHING-CHU LU Chang, Yi-Ru Chang, Yi-Yao CHI-SHENG HUNG SHIH-CHIEH CHUEH VIN-CENT WU CHENG-HSUAN TSAI YEN-HUNG LIN |
關鍵字: | Hyperaldosteronism; diabetes mellitus; left ventricular remodeling; primary aldosteronism | 公開日期: | 二月-2023 | 卷: | 71 | 期: | 2 | 來源出版物: | Journal of investigative medicine : the official publication of the American Federation for Clinical Research | 摘要: | The elevated aldosterone in primary aldosteronism (PA) is associated with increased insulin resistance and prevalence of diabetes mellitus (DM). Both aldosterone excess and DM lead to left ventricular (LV) pathological remodeling. In this study, we investigated the impact of DM on LV non-hemodynamic remodeling in patients with PA. We enrolled 665 PA patients, of whom 112 had DM and 553 did not. Clinical, biochemical, and echocardiographic data were analyzed at baseline and 1 year after adrenalectomy. LV non-hemodynamic remodeling was represented by inappropriate excess left ventricular mass index (ieLVMI), which was defined as the difference between left ventricular mass index (LVMI) and predicted left ventricular mass index (pLVMI). Propensity score matching (PSM) was used with age, sex, systolic, and diastolic blood pressure to adjust for baseline variables. After PSM, the patient characteristics were balanced between the DM and non-DM groups, except for fasting glucose, HbA1c, and lipid profile. A total of 111 DM and 419 non-DM patients were selected for further analysis. Compared to the non-DM group, the DM group had significantly higher ieLVMI and LVMI. After multivariable linear regression analysis, the presence of DM remained a significant predictor of increased ieLVMI. After adrenalectomy, ieLVMI decreased significantly in the non-DM group but not in DM group. The presence of DM in PA patients was associated with more prominent non-hemodynamic LV remodeling and less recovery after adrenalectomy. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/627957 | ISSN: | 1081-5589 1708-8267 |
DOI: | 10.1177/10815589221141840 |
顯示於: | 醫學院附設癌醫中心醫院(臺大癌醫) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。