https://scholars.lib.ntu.edu.tw/handle/123456789/628079
標題: | Multisystem inflammatory syndrome in children: A dysregulated autoimmune disorder following COVID-19 | 作者: | PING-ING LEE PO-REN HSUEH |
關鍵字: | COVID-19; Kawasaki disease; Multisystem inflammatory syndrome in children | 公開日期: | 16-一月-2023 | 來源出版物: | Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi | 摘要: | Multisystem inflammatory syndrome in children (MIS-C) is a dysregulated autoimmune-mediated illness in genetically susceptible patients following COVID-19 with an interval of 2-6 weeks. The median age of patients with MIS-C is 6-11 years. Most common manifestations are involvement of gastrointestinal tract, cardiovascular system, hematological system, and mucocutaneous system. Respiratory tract, neurological system, musculoskeletal system, and kidney are less frequently affected. Mucocutaneous manifestations and coronary artery abnormalities characteristic for Kawasaki disease (KD) may be observed in a significant proportion of MIS-C patients that may make the differential diagnosis be difficult for some patients, especially in the post-pandemic era. The mortality rate is 1-3%. Management and prognosis of MIS-C are similar to that of KD. MIS-C and KD may share a common pathogenic process. Based on the observation of MIS-C-like illness in uninfected neonates, i.e. multisystem inflammatory syndrome in neonates, both MIS-C and KD may be a consequence of dysregulated, over-exaggerated humoral immune responses triggered by a specific infectious agent. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/628079 | ISSN: | 16841182 | DOI: | 10.1016/j.jmii.2023.01.001 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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