https://scholars.lib.ntu.edu.tw/handle/123456789/628220
標題: | Defective determination of synthetic cathinones in blood for forensic investigation | 作者: | Chen, Ju-Yu GUAN-YUAN CHEN Ong, Hooi-Nee Lai, Mei-Ling Ho, Yi-Ju CHING-HUA KUO TE-I WENG |
關鍵字: | Blood collection tubes; Forensic toxicology; LC-MS/MS; Synthetic cathinones | 公開日期: | 15-一月-2023 | 出版社: | ELSEVIER | 卷: | 539 | 起(迄)頁: | 122 | 來源出版物: | Clinica chimica acta; international journal of clinical chemistry | 摘要: | Antemortem specimens are sometimes the sole sources available for forensic investigation, and samples collected in nonideal ways are inevitably employed to achieve toxicological analysis. It is essential to assess the effects of blood collection tubes on the recoveries of emerging synthetic cathinones (SC) to estimate actual drug concentrations, and no such systematic investigations have been previously carried out. Seventy-one SC with various LogP values were employed to examine commonly used blood collection tubes, including plasma tubes, serum tubes and gel-containing tubes in recoveries which determined by a reliable LC-MS/MS method. Significantly poor recoveries for hydrophobic SC were obtained using serum separating tubes (SST). Notably, the suppressed recoveries in SST can be reversed by adding anticoagulants. Adding a procoagulant to a plasma separating tube (PST) considerably reduced recoveries, which indicated that clotting processes in the presence of polymeric gels contributed to poor recoveries of these hydrophobic drugs. In this study, we find that clotting formation in the presence of polymeric gels could significantly affect the determination of hydrophobic drugs. However, in real-world scenarios, nonideal collection methods are inevitably employed for antemortem specimens. Thus, it is important to rigorously interpret forensic toxicological results, especially for susceptible species. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/628220 | ISSN: | 0009-8981 | DOI: | 10.1016/j.cca.2022.12.004 |
顯示於: | 法醫學科所 |
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