https://scholars.lib.ntu.edu.tw/handle/123456789/628581
標題: | Targeting histone deacetylase-3 blocked epithelial-mesenchymal plasticity and metastatic dissemination in gastric cancer | 作者: | Wu, Sheng-Mao Jan, Yee-Jee Tsai, Shih-Chuan Pan, Hung-Chuan Shen, Chin-Chang Yang, Cheng-Ning Lee, Shu-Hua SHING-HWA LIU Shen, Li-Wei Chiu, Chien-Shan Arbiser, Jack L Meng, Menghsiao Sheu, Meei-Ling |
關鍵字: | Endoplasmic reticulum stress; Epithelial–mesenchymal transition; Histone deacetylase 3; Histone deacetylase inhibitors; Peritoneal dissemination | 公開日期: | 1-一月-2022 | 出版社: | SPRINGER | 卷: | 39 | 起(迄)頁: | 1873–1896 | 來源出版物: | Cell Biology and Toxicology | 摘要: | Histone deacetylase (HDAC) inhibitors (HDIs) can modulate the epithelial-mesenchymal transition (EMT) progression and inhibit the migration and invasion of cancer cells. Emerging as a novel class of anti-cancer drugs, HDIs are attracted much attention in the field of drug discovery. This study aimed to discern the underlying mechanisms of Honokiol in preventing the metastatic dissemination of gastric cancer cells by inhibiting HDAC3 activity/expression. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/628581 | ISSN: | 0742-2091 | DOI: | 10.1007/s10565-021-09673-2 |
顯示於: | 毒理學研究所 |
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