https://scholars.lib.ntu.edu.tw/handle/123456789/628655
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Charmetant, Xavier | en_US |
dc.contributor.author | CHIEN-CHIA CHEN | en_US |
dc.contributor.author | Hamada, Sarah | en_US |
dc.contributor.author | Goncalves, David | en_US |
dc.contributor.author | Saison, Carole | en_US |
dc.contributor.author | Rabeyrin, Maud | en_US |
dc.contributor.author | et al., | en_US |
dc.date.accessioned | 2023-02-22T02:00:33Z | - |
dc.date.available | 2023-02-22T02:00:33Z | - |
dc.date.issued | 2022-09-21 | - |
dc.identifier.issn | 1946-6234 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/628655 | - |
dc.description.abstract | The generation of antibodies against donor-specific major histocompatibility complex (MHC) antigens, a type of donor-specific antibodies (DSAs), after transplantation requires that recipient's allospecific B cells receive help from T cells. The current dogma holds that this help is exclusively provided by the recipient's CD4+ T cells that recognize complexes of recipient's MHC II molecules and peptides derived from donor-specific MHC alloantigens, a process called indirect allorecognition. Here, we demonstrated that, after allogeneic heart transplantation, CD3ε knockout recipient mice lacking T cells generate a rapid, transient wave of switched alloantibodies, predominantly directed against MHC I molecules. This is due to the presence of donor CD4+ T cells within the graft that recognize intact recipient's MHC II molecules expressed by B cell receptor-activated allospecific B cells. Indirect evidence suggests that this inverted direct pathway is also operant in patients after transplantation. Resident memory donor CD4+ T cells were observed in perfusion liquids of human renal and lung grafts and acquired B cell helper functions upon in vitro stimulation. Furthermore, T follicular helper cells, specialized in helping B cells, were abundant in mucosa-associated lymphoid tissue of lung and intestinal grafts. In the latter, more graft-derived passenger T cells correlated with the detection of donor T cells in recipient's circulation; this, in turn, was associated with an early transient anti-MHC I DSA response and worse transplantation outcomes. We conclude that this inverted direct allorecognition is a possible explanation for the early transient anti-MHC DSA responses frequently observed after lung or intestinal transplantations. | en_US |
dc.language.iso | en | en_US |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | en_US |
dc.relation.ispartof | Science translational medicine | en_US |
dc.subject | MEDIATED REJECTION; HLA ANTIBODIES; MONOCLONAL-ANTIBODY; CELLULAR REJECTION; T-CELLS; ALLOGRAFT; PATHWAY; ALLOANTIBODY; LUNG; ENGAGEMENT | en_US |
dc.title | Inverted direct allorecognition triggers early donor-specific antibody responses after transplantation | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1126/scitranslmed.abg1046 | - |
dc.identifier.pmid | 36130013 | - |
dc.identifier.scopus | 2-s2.0-85138234579 | - |
dc.identifier.isi | WOS:000869432500004 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85138234579 | - |
dc.relation.journalvolume | 14 | en_US |
dc.relation.journalissue | 663 | en_US |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.orcid | 0000-0002-1282-976X | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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