標題: | Rare coding variants in RCN3 are associated with blood pressure |
作者: | He, Karen Y Kelly, Tanika N Wang, Heming Liang, Jingjing Zhu, Luke Cade, Brian E Assimes, Themistocles L Becker, Lewis C Beitelshees, Amber L Bielak, Lawrence F Bress, Adam P Brody, Jennifer A Chang, Yen-Pei Christy YI-CHENG CHANG de Vries, Paul S Duggirala, Ravindranath Fox, Ervin R Franceschini, Nora Furniss, Anna L Gao, Yan Guo, Xiuqing Haessler, Jeffrey Hung, Yi-Jen Hwang, Shih-Jen Irvin, Marguerite Ryan Kalyani, Rita R Liu, Ching-Ti Liu, Chunyu Martin, Lisa Warsinger Montasser, May E Muntner, Paul M Mwasongwe, Stanford Naseri, Take Palmas, Walter Reupena, Muagututi'a Sefuiva Rice, Kenneth M Sheu, Wayne H-H Shimbo, Daichi Smith, Jennifer A Snively, Beverly M Yanek, Lisa R Zhao, Wei Blangero, John Boerwinkle, Eric Chen, Yii-Der Ida Correa, Adolfo Cupples, L Adrienne Curran, Joanne E Fornage, Myriam He, Jiang Hou, Lifang Kaplan, Robert C Kardia, Sharon L R Kenny, Eimear E Kooperberg, Charles Lloyd-Jones, Donald Loos, Ruth J F Mathias, Rasika A McGarvey, Stephen T Mitchell, Braxton D North, Kari E Peyser, Patricia A Psaty, Bruce M Raffield, Laura M Rao, D C Redline, Susan Reiner, Alex P Rich, Stephen S Rotter, Jerome I Taylor, Kent D Tracy, Russell Vasan, Ramachandran S Morrison, Alanna C Levy, Daniel Chakravarti, Aravinda Arnett, Donna K Zhu, Xiaofeng |
關鍵字: | Blood pressure; Rare variant analysis; Whole genome sequencing |
公開日期: | 19-二月-2022 |
出版社: | BMC |
卷: | 23 |
期: | 1 |
來源出版物: | BMC Genomics |
摘要: | While large genome-wide association studies have identified nearly one thousand loci associated with variation in blood pressure, rare variant identification is still a challenge. In family-based cohorts, genome-wide linkage scans have been successful in identifying rare genetic variants for blood pressure. This study aims to identify low frequency and rare genetic variants within previously reported linkage regions on chromosomes 1 and 19 in African American families from the Trans-Omics for Precision Medicine (TOPMed) program. Genetic association analyses weighted by linkage evidence were completed with whole genome sequencing data within and across TOPMed ancestral groups consisting of 60,388 individuals of European, African, East Asian, Hispanic, and Samoan ancestries. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125020296&doi=10.1186%2fs12864-022-08356-4&partnerID=40&md5=16ec67e1bd56a6d63a56b4aa7e44ae9d https://scholars.lib.ntu.edu.tw/handle/123456789/628727 |
ISSN: | 1471-2164 |
DOI: | 10.1186/s12864-022-08356-4 |
顯示於: | 基因體暨蛋白體醫學研究所
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