https://scholars.lib.ntu.edu.tw/handle/123456789/628822
標題: | Spectral-domain optical coherence tomography for evaluating palisades of Vogt in ocular surface disorders with limbal involvement | 作者: | Chen, Ying Yi Sun, Yi Chen Tsai, Chia Ying HSIAO-SANG CHU Wu, Jo Hsuan Chang, Huai Wen WEI-LI CHEN |
關鍵字: | ANTERIOR SEGMENT; STEM-CELLS; MANAGEMENT; FEATURES; NICHE | 公開日期: | 1-十二月-2021 | 出版社: | NATURE PORTFOLIO | 卷: | 11 | 期: | 1 | 來源出版物: | Scientific Reports | 摘要: | Spectral-domain optical coherence tomography (SD-OCT) has been used to observe the morphology of the palisades of Vogt (POV) with satisfactory resolutions. In this study, we used SD-OCT to examine the microstructure of the POV in ocular surface disorders with limbal involvement. We detect subclinical limbal pathologies based on five parameters, including (1) decreased epithelial thickness, (2) loss of the sharp stromal tip, (3) loss of the smooth epithelial-stromal interface, (4) dilated stromal vessels, and (5) decreased POV density. Eighteen eyes of 10 patients with advancing wavelike epitheliopathy (AWE) and 15 eyes of 9 patients with phlyctenular keratitis/ocular rosacea were recruited. SD-OCT could detect abnormal changes in the POV in 100% of the lesion sites. In presumed-healthy areas of the diseased eyes diagnosed by slit-lamp biomicroscopy, SD-OCT detected abnormal changes in the POV in 100% of the eyes in both groups. In patients with unilateral disease, abnormal changes in the POV were detected by SD-OCT in 50% and 100% of presumed-healthy eyes diagnosed by slit-lamp biomicroscopy in the AWE group and phlyctenular keratitis/ocular rosacea group, respectively. SD-OCT is powerful in detecting POV changes in ocular surface disorders and can provide useful information that cannot be provided by slit-lamp biomicroscopy. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/628822 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-021-91999-2 |
顯示於: | 醫學系 |
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