https://scholars.lib.ntu.edu.tw/handle/123456789/628908
標題: | Lack of effects of four-week theta burst stimulation on white matter macro/microstructure in children and adolescents with autism | 作者: | Ni, Hsing-Chang Chao, Yi-Ping Tseng, Rung-Yu Wu, Chen-Te Cocchi, Luca TAI-LI CHOU Chen, Rou-Shayn SUSAN SHUR-FEN GAU Yeh, Chun-Hung Lin, Hsiang-Yuan |
關鍵字: | Autism; Diffusion MRI; Posterior superior temporal sulcus; Randomized controlled trial; Theta burst stimulation; Transcranial magnetic stimulation | 公開日期: | 7-一月-2023 | 卷: | 37 | 來源出版物: | NeuroImage. Clinical | 摘要: | Following the published behavioral and cognitive results of this single-blind parallel sham-controlled randomized clinical trial, the current study aimed to explore the impact of intermittent theta burst stimulation (iTBS), a variant of excitatory transcranial magnetic stimulation, over the bilateral posterior superior temporal sulci (pSTS) on white matter macro/microstructure in intellectually able children and adolescents with autism. Participants were randomized and blindly received active or sham iTBS for 4 weeks (the single-blind sham-controlled phase). Then, all participants continued to receive active iTBS for another 4 weeks (the open-label phase). The clinical results were published elsewhere. Here, we present diffusion magnetic resonance imaging data on potential changes in white matter measures after iTBS. Twenty-two participants in Active-Active group and 27 participants in Sham-Active group underwent multi-shell high angular resolution diffusion imaging (64-direction for b = 2000 & 1000 s/mm2, respectively) at baseline, week 4, and week 8. With longitudinal fixel-based analysis, we found no white matter changes following iTBS from baseline to week 4 (a null treatment by time interaction and a null within-group paired comparison in the Active-Active group), nor from baseline to week 8 (null within-group paired comparisons in both Active-Active and Sham-Active groups). As for the brain-symptoms relationship, we did not find baseline white matter metrics associated with symptom changes at week 4 in either group. Our results raise the question of what the minimal cumulative stimulation dose required to induce the white matter plasticity is. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/628908 | ISSN: | 22131582 | DOI: | 10.1016/j.nicl.2023.103324 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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