https://scholars.lib.ntu.edu.tw/handle/123456789/628951
標題: | Using range of motion to examine the effects of deep brain stimulation on gait function of Parkinson’s disease patients with freezing of gait: a proof-of-concept study | 作者: | Nien, C. KAI-HSIANG CHEN Wu, Y.-N. Chuang, S.-L. Yang, B.-S. |
關鍵字: | Deep brain stimulation | Freezing of gait | Range of motion | 公開日期: | 2021 | 卷: | 16 | 期: | 2 | 來源出版物: | Journal of Biomechanical Science and Engineering | 摘要: | The purpose of this study was to develop quantitative parameters using range of motion (ROM) of shanks, thighs and knees to evaluate the effect of deep brain stimulation (DBS) on gait performance and freezing of gait (FOG) of patients with advanced Parkinson’s disease (PD). Three patients with FOG due to advanced Parkinson’s disease who has received DBS were recruited. The recruited subjects were instructed to walk on a 100-meter path in three conditions: 60 Hz DBS (60 Hz), 130 Hz DBS (130 Hz) and no DBS (Off). Five inertial measurement unit sensors were attached to subjects’ sacrum, bilateral shanks and thighs respectively. Quantified parameters included (1) spatial parameters: shanks, thighs and knees ROM; (2) temporal parameters: stride time, stance time duration and double support time percentage; (3) FOG severity: the percentage of FOG duration during path walking. Three subjects’ ROM of right shank significantly increased in 60 Hz,130 Hz and Off order. Compared to 130 Hz, right shank ROM of subjects S1, S2 and S3 significantly increased 13.2%, 99.6% and 6.1% in 60 Hz, respectively. In temporal parameters results, only double support time percentage was significantly different between 60 Hz and 130 Hz in all three subjects. When compared to 130 Hz, the double support time percentage of S1 and S2 significantly decreased 6.3% and 18.4% in 60 Hz, and that of S3 significantly increased 4.4%. ROM of right shank and FOG severity were highly correlated (R2 = 0.71). Shank ROM could represent subjects’ gait performance under different stimulation conditions. Shank ROM could be treated as a reference for clinicians to evaluate gait performance and severity of FOG immediately when DBS frequency is adjusted. This study demonstrated the potential of using objective parameters to optimize the DBS through assessing the gait performance changes in the clinic. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/628951 | ISSN: | 18809863 | DOI: | 10.1299/JBSE.21-00093 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。