https://scholars.lib.ntu.edu.tw/handle/123456789/629219
標題: | Fat mass as an important predictor of persistent hypertension in patients with primary aldosteronism after adrenalectomy | 作者: | Huang, Wei-Chieh Chen, Ying-Ying SHAO-YU YANG CHUN-FU LAI TAI-SHUAN LAI Chen, Hsiang-Yao Chen, LiWei Wang, Yi-Jen Cheng, Yu-Lun Lang, Cheng-Lin Chen, Chih-Fan Chang, Hui-Fang JEN-KUEI PENG Lin, Liang-Yu Cheng, Hao-Min Hwu, Chii-Min Lu, Tse-Min SHIH-CHIEH CHUEH YEN-HUNG LIN VIN-CENT WU |
關鍵字: | Adrenalectomy; Bioimpedance; Fat Mass; Normal Weight Obesity; Primary aldosteronism | 公開日期: | 9-二月-2023 | 來源出版物: | Hypertension research : official journal of the Japanese Society of Hypertension | 摘要: | Aldosterone excess is present in obesity and is associated with involvement in the pathogenesis of obesity. We evaluate the impact of body obesity as measured by body composition monitor (BCM) on clinical outcomes in patients with unilateral primary aldosteronism (uPA) after adrenalectomy. The BCM device was used to assess body composition before and after adrenalectomy. We used fat mass (FM) and body mass index (BMI) to classify obesity and divided obesity into three groups: clinical overweight (BMI (kg/m2) ≥25); normal weight obesity (NWO, FM (%) ≥ 35 for women, >25 for men & BMI < 25); and no obesity (FM < 35 for women, <25 for men & BMI < 25). A total of 130 unilateral PA (uPA) patients received adrenalectomy, and 27 EH patients were identified; uPA patients with hypertension remission were found to have lower FM (p = 0.046), BMI (p < 0.001), and lower prevalence of overweight (p = 0.001). In the logistic regression model, patients with clinical overweight (OR = 2.9, p = 0.007), NWO (OR = 3.04, p = 0.041) and longer HTN duration (years, OR = 1.065, p = 0.013) were at the risk of persistent hypertension after adrenalectomy. Obesity status was strongly associated with persistent hypertension in uPA patients after adrenalectomy. However, patients in the NWO group also carried higher risk of persistent hypertension. Therefore, assessment of pre-obesity and overweight in uPA patients are extremely important, especially in those who have normal BMI. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/629219 | ISSN: | 09169636 | DOI: | 10.1038/s41440-023-01203-3 |
顯示於: | 醫學系 |
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