https://scholars.lib.ntu.edu.tw/handle/123456789/629362
標題: | Cisplatin-loaded gold nanoshells mediate chemo-photothermal therapy against primary and distal lung cancers growth | 作者: | Yang, Shu-Jyuan Pai, Jui-An MING-JIUM SHIEH JENNY LING-YU CHEN KE-CHENG CHEN |
關鍵字: | Chemotherapy; Cisplatin; Combination therapy; Gold nanoshell; Human serum albumin; Photothermal therapy | 公開日期: | 二月-2023 | 出版社: | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | 卷: | 158 | 來源出版物: | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | 摘要: | Lung cancer is the most common cause of cancer mortality worldwide. The advances in surgery, radiotherapy, chemotherapeutic and immunotherapeutic drugs have progressed in the past decades, but the prognosis of lung cancer is still poor. In this study, we developed cisplatin (CDDP)-loaded human serum albumin (HSA)-based gold nanoshells (HCP@GNSs) for synergistic chemo-photothermal therapy (chemo-PTT). The HCP@GNSs not only acted as drug nanocarriers for chemotherapy but also serve as a superior mediator for PTT, which could exhibit a temperature increase upon a near infrared (NIR) laser exposure that was sufficient for photothermal ablation. HCP@GNSs were highly biocompatible and hemocompatible nanocarriers, while the synergistic chemo-PTT resulting from HCP@GNSs plus NIR exposure displayed stronger cytotoxicity effect than HCP@GNSs or PTT alone, especially at a low CDDP concentration. In vivo analysis demonstrated that HCP@GNSs-mediated chemo-PTT increased necrosis in tumors to achieve a high tumor clearance rate with no adverse side effects. Moreover, HCP@GNSs-medicated chemo-PTT induced the recruitment of dendritic cells, B-cells, and natural killer T-cells in distal tumors to inhibit the growth of the tumors. Therefore, the CDDP-loaded HCP@GNSs may be a potential nanomedicine candidate for curative lung cancer treatment in the future. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/629362 | ISSN: | 0753-3322 | DOI: | 10.1016/j.biopha.2022.114146 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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