https://scholars.lib.ntu.edu.tw/handle/123456789/629544
標題: | THC:YAG laser sclerostomy with preoperative mitomycin-C subconjunctival injection in rabbits | 作者: | Wang, Tsing Hong Hung, Por T. TZYY-CHANG HO |
關鍵字: | Mitomycin-C | Sclerostomy | THC:YAG laser | 公開日期: | 1-一月-1993 | 卷: | 2 | 期: | 4 | 來源出版物: | Journal of Glaucoma | 摘要: | Subconjunctival fibrosis is one of the major causes of most bleb failures. To inhibit the wound-healing process and to achieve a better intraocular pressure (IOP) lowering effect as well as bleb formation, we performed a sclerostomy using a THC: YAG laser (thulium, holmium, and chromium-doped yttrium-aluminum-garnet crystal) and a subconjunctival injection of mitomycin-C given 24 h or 5 days before a filtering operation or soon after the filtering process in rabbits. A 1-mm conjunctiva wound was made 12 mm away from the sclerostomy site to allow for entry of an optic probe for delivering energy. Forty-eight rabbits were divided into four groups. Group I received a subconjunctival injection of 0.2 ml of 0.2 mg/ml of mitomycin-C 24 h before the operation. The same dosage of mitomycin-C was given to Group II 5 days before the operation and to Group III immediately following the operation. Group IV served as a control, and only 0.2 ml of normal saline solution was given 24 h preoperatively. One eye of each rabbit was randomly selected for the experiment, while the other eye served as a control. The bleb lasted 30.9 ± 15.7 days in Group I, 16.0 ± 6.4 days in Group II, 15.5 ± 6.5 days in Group III, and 2.3 ± 0.7 days in Group IV. The IOP lowering effect was parallel to bleb formation. The results demonstrate that a subconjunctival mitomycin-C injection given 24 h before a filtering operation is more effective in prolonging the filtering effect produced by the THC:YAG laser than one given postoperatively. © Williams & Wilkins 1993. All Rights Reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/629544 | ISSN: | 10570829 |
顯示於: | 醫學系 |
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