https://scholars.lib.ntu.edu.tw/handle/123456789/629632
標題: | Functional chicken-liver hydrolysates ameliorate insulin resistance and cognitive decline in streptozotocin-induced diabetic mice | 作者: | Yeh, Wei-Yu Lin, Yi-Ling WEN-YUAN YANG CHUNG-HSI CHOU Wu, Yi-Hsieng Samuel YI-CHEN CHEN |
關鍵字: | STZ-induced hyperglycemia; apoptosis; chicken-liver hydrolysate; cognitive decline; oxidative stress | 公開日期: | 六月-2022 | 出版社: | ELSEVIER | 卷: | 101 | 期: | 6 | 來源出版物: | Poultry science | 摘要: | As part of the slaughtering processing in Taiwan, approximately 10,000 metric tons of broiler livers are produced yearly. However, these livers are regarded as waste. Our team has successfully developed a functional chicken-liver hydrolysate (CLH) with several useful activities. It has been reported that there is a positive relationship between diabetes mellitus (DM) patients and cognitive decline. To maximize broiler-livers' utilization and add value, we investigated the modulative effects of the CLHs on glucose homeostasis and cognitive decline in streptozotocin (STZ) induced diabetic mice. After a 9-wk experiment, CLH supplementation lowered blood glucose by increasing GLUT4 protein expressions in the brains, livers, and muscles of STZ-induced mice (P < 0.05). CLHs also enhanced antioxidant capacities in the livers and brains of STZ-induced mice. Amended memory and alternation behavior were tested by using water and Y-maze assays (P < 0.05). Besides, STZ-induced mice with CLH supplementation had less contracted neuron bodies in the hippocampus and lower (P < 0.05) Aβ depositions in the dentate gyrus area. Less AGE accumulation and apoptosis-related proteins (RAGE, JNK, and activated Caspase 3) in the brains of STZ-induced mice were also detected by supplementing CLHs (P < 0.05). In conclusion, the results from this study offer not only scientific evidence on the amelioration of insulin resistance and cognitive decline in hyperglycemia but also add value to this byproduct. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/629632 | ISSN: | 0032-5791 | DOI: | 10.1016/j.psj.2022.101887 |
顯示於: | 動物科學技術學系 |
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