https://scholars.lib.ntu.edu.tw/handle/123456789/629766
Title: | Chemical composition and anti-aging effects of standardized herbal chicken essence on D-galactose- induced senescent mice | Authors: | Wu, Shu-Jing Tung, Yi-Jou Yen, Ming-Hong LEAN-TEIK HUANG |
Keywords: | D-galactose; SIRT1; anti-aging; anti-inflammation; chicken essence | Issue Date: | 2022 | Publisher: | FRONTIERS MEDIA SA | Journal Volume: | 9 | Source: | Frontiers in nutrition | Abstract: | This study aimed to examine the chemical and anti-aging properties of chicken essence (CE) prepared with Sesamum indicum, Angelica acutiloba, and Zingiber officinale (HCE). HCE was analyzed for nutritional and phytochemical composition, and its anti-aging effects were investigated on the D-galactose (Gal)-induced aging mice. Results showed that HCE possessed significantly higher calories and contents of valine and total phenols than CE; it also contained significant amounts of ferulic acid, sesamin, and sesamolin. HCE significantly decreased MDA and NO levels in serum and liver and increased liver GSH levels in the D-Gal-induced mice. HCE greatly enhanced SOD and CAT activities in serum and liver, and liver GPx activity, as well as upregulating SIRT1 expression and downregulating TNF-α, IL-1β, IL-6, iNOS, Cox-2, and MCP-1 expression in liver tissues. This study demonstrates that HCE was effective in suppressing the aging process through enhancing antioxidant and anti-inflammatory activities and modulating the aging-related gene expression. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/629766 | ISSN: | 2296-861X | DOI: | 10.3389/fnut.2022.989067 |
Appears in Collections: | 農業化學系 |
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