https://scholars.lib.ntu.edu.tw/handle/123456789/629945
標題: | Amination Potentially Augments the Ameliorative Effect of Curcumin on Inhibition of the IL-6/Stat3/c-Myc Pathway and Gut Microbial Modulation in Colitis-Associated Tumorigenesis | 作者: | Koh, Yen-Chun Tsai, Yi-Wen Lee, Pei-Sheng Nagabhushanam, Kalyanam Ho, Chi-Tang MIN-HSIUNG PAN |
關鍵字: | amination; colitis; curcumin; gut microbiota; tumorigenesis | 公開日期: | 23-十一月-2022 | 出版社: | AMER CHEMICAL SOC | 卷: | 70 | 期: | 46 | 起(迄)頁: | 14744 | 來源出版物: | Journal of agricultural and food chemistry | 摘要: | Epigallocatechin gallate and tetrahydrocurcumin are aminated as colonic metabolites, preserving their bioactivities and improving their capabilities. We compared the bioactivities of unaminated (CUR) and aminated (AC) curcumin in inflammatory colitis-associated tumorigenesis. The anti-inflammatory and anticancer capabilities of CUR and AC were evaluated using RAW264.7 and HT29 cell lines, respectively. An azoxymethane/dextran sodium sulfate-induced colitis-associated carcinogenesis mouse model was used with CUR and two-dose AC interventions. AC had a greater anti-inflammatory effect but a similar anticancer effect as CUR in vitro. CUR and low-dose AC (LAC) significantly preserved colon length and reduced tumor number in vivo. Both CUR and LAC inhibited activation of the protein kinase B (AKT)/nuclear factor kappa B (NF-κB) signaling pathway, its downstream cytokines, and the interleukin (IL)-6/signal transducer and activator of transcription 3 (STAT3)/c-myelocytomatosis oncogene (c-MYC) pathway. However, only LAC significantly preserved E-cadherin, reduced N-cadherin, and facilitated beneficial gut microbial growth, including Akkermansia and Bacteroides, potentially explaining AC's better ameliorative effect at low than high doses. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/629945 | ISSN: | 0021-8561 | DOI: | 10.1021/acs.jafc.2c06645 |
顯示於: | 食品科技研究所 |
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