https://scholars.lib.ntu.edu.tw/handle/123456789/629945
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Koh, Yen-Chun | en_US |
dc.contributor.author | Tsai, Yi-Wen | en_US |
dc.contributor.author | Lee, Pei-Sheng | en_US |
dc.contributor.author | Nagabhushanam, Kalyanam | en_US |
dc.contributor.author | Ho, Chi-Tang | en_US |
dc.contributor.author | MIN-HSIUNG PAN | en_US |
dc.date.accessioned | 2023-03-31T02:04:31Z | - |
dc.date.available | 2023-03-31T02:04:31Z | - |
dc.date.issued | 2022-11-23 | - |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/629945 | - |
dc.description.abstract | Epigallocatechin gallate and tetrahydrocurcumin are aminated as colonic metabolites, preserving their bioactivities and improving their capabilities. We compared the bioactivities of unaminated (CUR) and aminated (AC) curcumin in inflammatory colitis-associated tumorigenesis. The anti-inflammatory and anticancer capabilities of CUR and AC were evaluated using RAW264.7 and HT29 cell lines, respectively. An azoxymethane/dextran sodium sulfate-induced colitis-associated carcinogenesis mouse model was used with CUR and two-dose AC interventions. AC had a greater anti-inflammatory effect but a similar anticancer effect as CUR in vitro. CUR and low-dose AC (LAC) significantly preserved colon length and reduced tumor number in vivo. Both CUR and LAC inhibited activation of the protein kinase B (AKT)/nuclear factor kappa B (NF-κB) signaling pathway, its downstream cytokines, and the interleukin (IL)-6/signal transducer and activator of transcription 3 (STAT3)/c-myelocytomatosis oncogene (c-MYC) pathway. However, only LAC significantly preserved E-cadherin, reduced N-cadherin, and facilitated beneficial gut microbial growth, including Akkermansia and Bacteroides, potentially explaining AC's better ameliorative effect at low than high doses. | en_US |
dc.language.iso | en | en_US |
dc.publisher | AMER CHEMICAL SOC | en_US |
dc.relation.ispartof | Journal of agricultural and food chemistry | en_US |
dc.subject | amination; colitis; curcumin; gut microbiota; tumorigenesis | en_US |
dc.title | Amination Potentially Augments the Ameliorative Effect of Curcumin on Inhibition of the IL-6/Stat3/c-Myc Pathway and Gut Microbial Modulation in Colitis-Associated Tumorigenesis | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1021/acs.jafc.2c06645 | - |
dc.identifier.pmid | 36368792 | - |
dc.identifier.scopus | 2-s2.0-85141995833 | - |
dc.identifier.isi | WOS:000885510700001 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85141995833 | - |
dc.relation.pages | 14744 | en_US |
dc.relation.journalvolume | 70 | en_US |
dc.relation.journalissue | 46 | en_US |
dc.relation.pageend | 14754 | en_US |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Food Science and Technology | - |
crisitem.author.orcid | 0000-0002-5188-7030 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
顯示於: | 食品科技研究所 |
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