https://scholars.lib.ntu.edu.tw/handle/123456789/630149
標題: | Risk of ischemic stroke in patients with hypertrophic cardiomyopathy in the absence of atrial fibrillation - a nationwide cohort study | 作者: | TING TSE LIN Sung, Yen-Ling Tsung-Yu Ko CHIH-KUO LEE LIAN-YU LIN JYH-MING JIMMY JUANG CHO-KAI WU |
關鍵字: | age;hypertrophic cardiomyopathy;risk of ischemic stroke | 公開日期: | 2-十二月-2019 | 出版社: | IMPACT JOURNALS LLC | 卷: | 11 | 期: | 23 | 起(迄)頁: | 11347 | 來源出版物: | Aging | 摘要: | Ischemic stroke (IS) is a catastrophic complication of hypertrophic cardiomyopathy (HCM) with aging. We investigated the incidence of IS in HCM patients without atrial fibrillation (AF) and compared the relative risk of IS with matched general population with AF. This study identified 17,371 HCM patients without AF and utilized propensity-score-matching to identify one-to-one matched control of general population with AF receiving oral anti-coagulants (OACs). During a median follow-up of 7.3 years, 847 (4.9%) subjects experienced IS with the incidence of 0.589/100 person-years. The corresponding matched controls experienced 788 (4.5%) events with the incidence of 0.494/100 person-years. Compared with control, HCM patients had similar risk of IS (Hazard ratios [HRs] 0.965, 95% confidence interval [CI] 0.854-1.091). HCM patients with age above 65 years had a significantly increased risk of IS (age 65-74 years, HR 1.278, 95% CI 1.070-1.335; age ≥75 years, HR 1.757, 95% CI 1.435-2.152). Stratified by CHA2DS2-VASc score, HCM subjects with score 0, 1 and 2 had significantly increased risk of IS than control while those with score ≥2 had similar risk as control. Compared with general population with AF, HCM patients without AF had similar risk of IS, suggesting OACs might be necessary in HCM patient without AF. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/630149 | ISSN: | 1945-4589 | DOI: | 10.18632/aging.102532 |
顯示於: | 醫學系 |
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