https://scholars.lib.ntu.edu.tw/handle/123456789/630696
標題: | Increased serum levels of betatrophin in pancreatic cancer-associated diabetes | 作者: | Susanto, Hendra Liu, Ta-Yu CHANG-CHIANG CHEN Purnomo, Jerry D T Chen, Shu-Fan Wang, Chih-Hong |
關鍵字: | betatrophin; diabetes; glucose intolerance; insulin resistance; pancreatic cancer | 公開日期: | 5-七月-2016 | 出版社: | IMPACT JOURNALS LLC | 卷: | 7 | 期: | 27 | 起(迄)頁: | 42330 | 來源出版物: | Oncotarget | 摘要: | Long-standing diabetes or glucose intolerance is recognized as a crucial event in the process of pancreatic cancer. Betatrophin, a novel liver-derived hormone, promotes β-cell proliferation and improves glucose intolerance. However, the relationship between betatrophin and PDAC-associated diabetes is not fully understood. To evaluate the serum betatrophin levels in PDAC-associated diabetes, a total 105 Taiwanese subjects including 15 healthy subjects, and 12 patients having PDAC with normal glucose tolerance (PDAC-NGT), 12 patients having PC with impaired glucose tolerance (PDAC-IGT), and 66 patients having PC with diabetes mellitus (PDAC-DM) were enrolled for this study. Serum betatrophin and carbohydrate antigen 19-9 (CA19-9) levels were analyzed by enzyme-linked immunosorbent assay (ELISA). Compared to healthy subjects, PDAC patients had higher levels of betatrophin and CA19-9. Consistently, betatrophin protein was significantly expressed in pancreatic ductal of PDAC-associated DM patients using immunohistochemistry (IHC) method. Furthermore, multivariate regression analysis showed the betatrophin was significantly and positively independent with T category (β= 0.605, P=0.010), serum albumin (β= 0. 423, P=0.021), lipase (β= 0.292, P=0.039), and blood urea nitrogen (BUN) (β= 0.303, P=0.040). Further, the betatrophin was three folds of having PDAC-associated diabetes with the highest odds ratio [OR=3.39; 95% CI (1.20-9.57); P=0.021) and receiver operating characteristic (ROC) curve analysis showed that AUC value of betarophin was 0.853 which is slightly larger than AUC value of CA19-9 (0.792) in PDAC-DM patients. Interestingly, AUC value of betarophin plus CA19-9 was 0.988 in PDAC-DM patients. Therefore, betatrophin combined CA19-9 may serve as a potential biomarker for PDAC-associated diabetes. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/630696 | ISSN: | 1949-2553 | DOI: | 10.18632/oncotarget.9815 |
顯示於: | 醫學系 |
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