https://scholars.lib.ntu.edu.tw/handle/123456789/630729
標題: | Enrichment of SOX2-Positive Cells in BRAF V600E Mutated and Recurrent Ameloblastoma | 作者: | Tseng, Chih Huang Lu, Pei Hsuan YI-PING WANG JULIA YU-FONG CHANG |
關鍵字: | Ameloblastoma | BRAF V600E | Recurrence | SOX2 | Stem cells | 公開日期: | 1-一月-2022 | 出版社: | MDPI | 卷: | 12 | 期: | 1 | 來源出版物: | Journal of Personalized Medicine | 摘要: | Ameloblastoma is the most common benign odontogenic neoplasm, but with an aggressive behavior and a high recurrence rate. Nowadays wide surgical resection is the current recommended treatment, which can cause further loss of function and esthetics. Recent studies point to the stem/progenitor cells as both initiators and propagators of the tumors. Elucidation of the cellular and molecular mechanisms underlying the tumor stem cells is of broad interest for understanding tumorigenesis and for developing effective targeted therapies. SRY related HMG box gene 2 (SOX2) is a transcription factor that plays important roles in development, stem cell renewal, and cancer formation. Few studies have revealed increased SOX2 expression in atypical ameloblastoma and ameloblastic carcinoma. For the development of personalized medicine for ameloblastoma, biomark-ers that provide prognostic or predictive information regarding a tumor’s nature or its response to treatment are essential. Thus, in this study, we aimed to study if SOX2-positive cells exist in ameloblas-tomas and their correlation with the clinicopathologic parameters. Our data suggested BRAF(V600E) mutation might contribute to the expansion of SOX2-positive cells. The identification of BRAF(V600E) mutation and the amplification of SOX2-positive cells in ameloblastomas imply the possible benefit of applying BRAF and SOX2 inhibitors in recurrent and un-resectable ameloblastomas. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/630729 | ISSN: | 2075-4426 | DOI: | 10.3390/jpm12010077 |
顯示於: | 牙醫學系 |
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