https://scholars.lib.ntu.edu.tw/handle/123456789/630762
標題: | Phenytoin induces connective tissue growth factor (CTGF/CCN2) production through NADPH oxidase 4-mediated latent TGFβ1 activation in human gingiva fibroblasts: Suppression by curcumin | 作者: | Deng Yiting KING-JEAN WU YEN-PING KUO |
關鍵字: | NADPH oxidase 4; curcumin; gingival overgrowth; phenytoin; reactive oxygen species; transforming growth factor beta | 公開日期: | 十二月-2022 | 出版社: | WILEY | 卷: | 57 | 期: | 6 | 起(迄)頁: | 1219 | 來源出版物: | Journal of periodontal research | 摘要: | Gingival overgrowth (GO) is a common side effect of some drugs such as anticonvulsants, immunosuppressant, and calcium channel blockers. Among them, the antiepileptic agent phenytoin is the most common agent related to this condition due to its high incidence. Transforming growth factor β (TGFβ) importantly contributes to the pathogenesis of GO. Connective tissue growth factor (CTGF or CCN2) is a key mediator of tissue fibrosis and is positively associated with the degree of fibrosis in GO. We previously showed that Src, c-jun N-terminal kinase, and Smad3 mediate TGFβ1-induced CCN2 protein expression in human gingival fibroblasts (HGFs). This study investigates whether phenytoin can induce CCN2 synthesis through activated latent TGFβ in HGFs and its mechanisms. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/630762 | ISSN: | 0022-3484 | DOI: | 10.1111/jre.13058 |
顯示於: | 牙醫學系 |
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