https://scholars.lib.ntu.edu.tw/handle/123456789/631364
標題: | LCRMP-1 is required for spermatogenesis and stabilises spermatid F-actin organization via the PI3K-Akt pathway | 作者: | Chang, Jung-Hsuan Chou, Chia-Hua JUI-CHING WU Liao, Keng-Mao Luo, Wei-Jia Hsu, Wei-Lun Chen, Xuan-Ren SUNG-LIANG YU SZU-HUA PAN PAN-CHYR YANG KANG-YI SU |
公開日期: | 10-四月-2023 | 卷: | 6 | 期: | 1 | 來源出版物: | Communications biology | 摘要: | Long-form collapsin response mediator protein-1 (LCRMP-1) belongs to the CRMP family which comprises brain-enriched proteins responsible for axon guidance. However, its role in spermatogenesis remains unclear. Here we find that LCRMP-1 is abundantly expressed in the testis. To characterize its physiological function, we generate LCRMP-1-deficient mice (Lcrmp-1-/-). These mice exhibit aberrant spermiation with apoptotic spermatids, oligospermia, and accumulation of immature testicular cells, contributing to reduced fertility. In the seminiferous epithelial cycle, LCRMP-1 expression pattern varies in a stage-dependent manner. LCRMP-1 is highly expressed in spermatids during spermatogenesis and especially localized to the spermiation machinery during spermiation. Mechanistically, LCRMP-1 deficiency causes disorganized F-actin due to unbalanced signaling of F-actin dynamics through upregulated PI3K-Akt-mTOR signaling. In conclusion, LCRMP-1 maintains spermatogenesis homeostasis by modulating cytoskeleton remodeling for spermatozoa release. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/631364 | ISSN: | 2399-3642 | DOI: | 10.1038/s42003-023-04778-2 |
顯示於: | 醫學檢驗暨生物技術學系 |
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