https://scholars.lib.ntu.edu.tw/handle/123456789/631654
標題: | A study on diabetogenic polypeptide. Preliminary report: isolation of diabetogenic polypeptide from the urines of proteinuric patients and its effect on glucose tolerance in rabbits and dogs | 作者: | TONG-YUAN TAI | 公開日期: | 一月-1976 | 卷: | 75 | 期: | 1 | 來源出版物: | Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association | 摘要: | By using acid alcohol precipitation method of Louis, various amounts of diabetogenic polypeptide were successfully isolated from the urines of 9 proteinuric diabetics, yet from the urines of 5 heavy proteinuric non diabetics, this polypeptide was not obtained at all. The polypeptide's diabetogenic effect was clearly demonstrated in all of 4 dogs 12 hours after the parenteral administration. Seventy two hours later, diminished glucose tolerance still sustained. However, only 2 of 6 rabbits showed reduced glucose tolerance in spite of receiving higher dose of the polypeptide. This discrepancy might result from the species difference of animals. The observation up to 2 hours after administration of the polypeptide to fasted dogs failed to find either stimulation of insulin release or decline of plasma glucose concentration. This substantiates the previous finding in isolated perfused rat pancreas that bovine pituitary diabetogenic polypeptide has no direct effect on insulin release. From the fact that successful isolation of this polypeptide confines to proteinuric diabetics, it seems likely that this polypeptide is overproduced from adenohypophyses of diabetics, and some extent of renal derangement has to be present before a substantial amount of this substance can be isolated with this method. The limited observation accords with the report of Louis, that mild diabetics without specific retinopathy are not necessarily the low excretors of the polypeptide. The implication of this polypeptide to the pathogenesis of idiopathic diabetes mellitus itself, diabetic retinopathy and the severity of diabetes is worthy of further investigation. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/631654 | ISSN: | 0371-7682 |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。