https://scholars.lib.ntu.edu.tw/handle/123456789/631869
標題: | Serum Mediators in Patients with Both Type 2 Diabetes Mellitus and Pruritus | 作者: | GUAN-YI HE Hsu, Tai-Yi Chen, Ching-Wen FENG-JUNG NIEN Chen, Huan-Yuan CHIA-YU CHU Wang, Li-Fang |
關鍵字: | chemokine CXCL10; diabetes mellitus; granulocyte-macrophage colony-stimulating factor; interleukin-4; interleu-kin-13; pruritus; GAMMA-INDUCIBLE PROTEIN-10; COLONY-STIMULATING FACTOR; UREMIC PRURITUS; IFN-GAMMA; CHEMOKINES; CYTOKINES; CXCR3; ITCH; KERATINOCYTES; ACTIVATION | 公開日期: | 28-二月-2023 | 出版社: | ACTA DERMATO-VENEREOLOGICA | 卷: | 103 | 來源出版物: | Acta dermato-venereologica | 摘要: | Chronic pruritus is an unpleasant sensory perception that negatively affects quality of life and is common among patients with type 2 diabetes mellitus. Current antipruritic therapies are insufficiently effective. Thus, the mediation of diabetic pruritus by histamine-independent pathways is likely. The aim of this study was to identify possible mediators responsible for diabetic pruritus. A total of 87 patients with type 2 diabetes mellitus were analysed, of whom 59 had pruritus and 28 did not. The 2 groups were assessed for baseline demographics, serum biochemistry parameters, cytokines, and chemokines. This study also investigated the associations of these factors with the severity of itching. Neither haemoglobin A1c nor serum creatinine levels were correlated with severity of itching. Significantly higher levels of interleukin-4 (p = 0.004), interleukin-13 (p = 0.006), granulocyte-macrophage colony-stimulating factor (p < 0.001) and C-X-C motif chemokine ligand 10 (p = 0.028) were observed in the patients with pruritus than in those without pruritus. Moreover, the levels of these mediators were positively correlated with the severity of itching. Thus, novel antipruritic drugs can be developed to target these molecules. This is the first study to compare inflammatory mediators comprehensively in patients with diabetes mellitus with pruritus vs those without pruritus. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/631869 | ISSN: | 0001-5555 | DOI: | 10.2340/actadv.v103.4863 |
顯示於: | 醫學院附設癌醫中心醫院(臺大癌醫) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。