https://scholars.lib.ntu.edu.tw/handle/123456789/631957
標題: | Hypocretin in locus coeruleus and dorsal raphe nucleus mediates inescapable footshock stimulation (IFS)-induced REM sleep alteration | 作者: | Lo, Yun Yi, Pei Lu YI-TSE HSIAO FANG-CHIA CHANG |
關鍵字: | dorsal raphe nucleus; hypocretin; inescapable footshock stimulation (IFS); lateral hypothalamus; locus coeruleus; REM sleep | 公開日期: | 1-三月-2022 | 出版社: | OXFORD UNIV PRESS INC | 卷: | 45 | 期: | 3 | 來源出版物: | Sleep | 摘要: | Hypocretin (hcrt) is a stress-reacting neuropeptide mediating arousal and energy homeostasis. An inescapable footshock stimulation (IFS) could initiate the hcrt release from the lateral hypothalamus (LHA) and suppresses rapid eye movement (REM) sleep in rodents. However, the effects of the IFS-induced hcrts on REM-off nuclei, the locus coeruleus (LC) and dorsal raphe nucleus (DRN), remained unclear. We hypothesized that the hcrt projections from the LHA to LC or DRN mediate IFS-induced sleep disruption. Our results demonstrated that the IFS increased hcrt expression and the neuronal activities in the LHA, hypothalamus, brainstem, thalamus, and amygdala. Suppressions of REM sleep and slow wave activity during non-REM (NREM) sleep caused by the high expression of hcrts were blocked when a nonspecific and dual hcrt receptor antagonist was administered into the LC or DRN. Furthermore, the IFS also caused an elevated innate anxiety, but was limitedly influenced by the hcrt antagonist. This result suggests that the increased hcrt concentrations in the LC and DRN mediate stress-induced sleep disruptions and might partially involve IFS-induced anxiety. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85126389348&doi=10.1093%2fsleep%2fzsab301&partnerID=40&md5=5fd2a8ca8a376930b0046d84c0daabc6 https://scholars.lib.ntu.edu.tw/handle/123456789/631957 |
ISSN: | 01618105 | DOI: | 10.1093/sleep/zsab301 |
顯示於: | 獸醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。