https://scholars.lib.ntu.edu.tw/handle/123456789/633039
Title: | Characteristics and response of subretinal hyperreflective material to anti-vascular endothelial growth factor in myopic choroidal neovascularization | Authors: | Huang, Chien Jung Hsia, Yun Wang, Shih Wen Ma, I. Hsin Tsui, Mei Chi Hung, Kuo Chi TZYY-CHANG HO |
Keywords: | INTRAVITREAL AFLIBERCEPT INJECTION; RANIBIZUMAB; BEVACIZUMAB; PREVALENCE; SECONDARY; OUTCOMES; THERAPY | Issue Date: | 1-Dec-2023 | Publisher: | NATURE PORTFOLIO | Journal Volume: | 13 | Journal Issue: | 1 | Source: | Scientific Reports | Abstract: | This retrospective study evaluated the characteristics and response of subretinal hyperreflective material (SHRM) to anti-vascular endothelial growth factor (VEGF) treatment in eyes with myopic choroidal neovascularization (CNV). The visual acuity (VA) was assessed at 3, 6, and 12 months after initiating anti-VEGF treatment in 116 patients (119 eyes) with SHRM and myopic CNV. Multimodal imaging, including color fundus photography, fluorescein angiography (FA), and optical coherence tomography angiography (OCT-A), were performed. We compared type 2 neovascularization (NV) (n = 64), subretinal hyperreflective exudation (SHE) (n = 37), NV with hemorrhage (n = 15), and fibrosis (n = 3). The type 2 NV group, and NV with hemorrhage groups showed significant VA improvement after 12 months of treatment (p < 0.05 in both groups); the SHE group failed to show improvement (p = 0.366). All groups showed a significant reduction in central foveal thickness after 12 months of treatment (all p < 0.05). The SHE group had a significantly higher incidence of interrupted ellipsoid zone than the other groups (p < 0.05). Myopic CNV can present as SHRM on OCT-A. Visual prognoses vary in different SHRM types. OCT-A and FA may help predict the outcomes of different subtypes of myopic CNV. SHE is predictive of outer retinal layer atrophy in patients with various SHRM types. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/633039 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-023-32417-7 |
Appears in Collections: | 醫學系 |
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