https://scholars.lib.ntu.edu.tw/handle/123456789/633132
標題: | Hepatitis D double reflex testing of all hepatitis B carriers in low-HBV- and high-HBV/HDV-prevalence countries | 作者: | Razavi, Homie A. Buti, Maria Terrault, Norah A. Zeuzem, Stefan Yurdaydin, Cihan Tanaka, Junko Aghemo, Alessio Akarca, Ulus S. Al Masri, Nasser M. Alalwan, Abduljaleel M. Aleman, Soo Alghamdi, Abdullah S. Alghamdi, Saad Al-Hamoudi, Waleed K. Aljumah, Abdulrahman A. Altraif, Ibrahim H. Asselah, Tarik Ben-Ari, Ziv Berg, Thomas Biondi, Mia J. Blach, Sarah Braga, Wornei S.M. Brandão-Mello, Carlos E. Brunetto, Maurizia R. Cabezas, Joaquin Cheinquer, Hugo PEI-JER CHEN Cheon, Myeong Eun Chuang, Wan Long Coffin, Carla S. Coppola, Nicola Craxi, Antonio Crespo, Javier De Ledinghen, Victor Duberg, Ann Sofi Etzion, Ohad Ferraz, Maria Lucia G. Ferreira, Paulo R.A. Forns, Xavier Foster, Graham R. Gaeta, Giovanni B. Gamkrelidze, Ivane García-Samaniego, Javier Gheorghe, Liliana S. Gholam, Pierre M. Gish, Robert G. Glenn, Jeffrey Hercun, Julian Hsu, Yao Chun Hu, Ching Chih Huang, Jee Fu Janjua, Naveed Jia, Jidong Kåberg, Martin Kaita, Kelly D.E. Kamal, Habiba JIA-HORNG KAO Kondili, Loreta A. Lagging, Martin Lázaro, Pablo Lazarus, Jeffrey V. Lee, Mei Hsuan Lim, Young Suk Marotta, Paul J. Navas, Maria Cristina Naveira, Marcelo C.M. Orrego, Mauricio Osiowy, Carla Pan, Calvin Q. Pessoa, Mário G. Raimondo, Giovanni Ramji, Alnoor Razavi-Shearer, Devin M. Razavi-Shearer, Kathryn Ríos-Hincapié, Cielo Y. Rodríguez, Manuel Rosenberg, William M.C. Roulot, Dominique M. Ryder, Stephen D. Safadi, Rifaat Sanai, Faisal M. Santantonio, Teresa A. Sarrazin, Christoph Shouval, Daniel Tacke, Frank Tergast, Tammo L. Villalobos-Salcedo, Juan Miguel Voeller, Alexis S. Yang, Hwai I. Yu, Ming Lung Zuckerman, Eli |
關鍵字: | HDV | Hepatitis D virus | 公開日期: | 1-一月-2023 | 來源出版物: | Journal of Hepatology | 摘要: | Hepatitis D virus (HDV) infection occurs as a coinfection with hepatitis B and increases the risk of hepatocellular carcinoma, decompensated cirrhosis, and mortality compared to hepatitis B virus (HBV) monoinfection. Reliable estimates of the prevalence of HDV infection and disease burden are essential to formulate strategies to find coinfected individuals more effectively and efficiently. The global prevalence of HBV infections was estimated to be 262,240,000 in 2021. Only 1,994,000 of the HBV infections were newly diagnosed in 2021, with more than half of the new diagnoses made in China. Our initial estimates indicated a much lower prevalence of HDV antibody (anti-HDV) and HDV RNA positivity than previously reported in published studies. Accurate estimates of HDV prevalence are needed. The most effective method to generate estimates of the prevalence of anti-HDV and HDV RNA positivity and to find undiagnosed individuals at the national level is to implement double reflex testing. This requires anti-HDV testing of all hepatitis B surface antigen-positive individuals and HDV RNA testing of all anti-HDV-positive individuals. This strategy is manageable for healthcare systems since the number of newly diagnosed HBV cases is low. At the global level, a comprehensive HDV screening strategy would require only 1,994,000 HDV antibody tests and less than 89,000 HDV PCR tests. Double reflex testing is the preferred strategy in countries with a low prevalence of HBV and those with a high prevalence of both HBV and HDV. For example, in the European Union and North America only 35,000 and 22,000 cases, respectively, will require anti-HDV testing annually. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/633132 | ISSN: | 01688278 | DOI: | 10.1016/j.jhep.2023.02.041 |
顯示於: | 臨床醫學研究所 |
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