https://scholars.lib.ntu.edu.tw/handle/123456789/633265
標題: | Nanodiamonds in Oil Emulsions Elicit Immune Responses for Safe and Effective Vaccination | 作者: | Lin, Hsin-Hung Wang, Chih-Yen Hsieh, Feng-Jen Liao, Fang-Zhen Su, Yu-Kai Pham, Minh Dinh CHIH-YUAN LEE Chang, Huan-Cheng HSAO-HSUN HSU |
關鍵字: | Adjuvants; antitumor agents; fluorescent nanodiamonds; ovalbumin; vaccine | 公開日期: | 7-二月-2023 | 來源出版物: | SSRN | 摘要: | The use of nanodiamonds (NDs) as biocompatible non-allergic additives in incomplete Freund’s adjuvant (IFA) to elicit immune responses is investigated. With chicken egg ovalbumin (OVA) as model antigens, experiments of mice immunized with OVA and OVA/ND in IFA showed that this new formulation could significantly enhance the immune responses and reduce the consumption of antigens to produce the antibodies of interest. It serves well as a safe and effective vaccine adjuvant without the need of inactivated mycobacteria pathogens that could cause many allergic reactions. In addition, the composites exhibited distinct therapeutic activities, as proven by the OVA/ND/IFA treatment which could effectively inhibit the tumor progression of OVA-expressing E.G7 cells inoculated in mice over 35 days. About 0.2% of the injected ND particles were found in mouse spleens on day 24. The multiple functionality of ND makes it useful as an active and trackable component of a vaccine adjuvant. © 2023, The Authors. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/633265 | ISSN: | 15565068 | DOI: | 10.2139/ssrn.4334118 |
顯示於: | 醫學系 |
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