https://scholars.lib.ntu.edu.tw/handle/123456789/633295
標題: | Multi-ethnic Imputation System (MI-System): A genotype imputation server for high-dimensional data | 作者: | Chattopadhyay, Amrita Lee, Chien-Yueh Shen, Ying-Cheng Lu, Kuan-Chen Hsiao, Tzu-Hung Lin, Ching-Heng LIANG-CHUAN LAI Tsai, Mong-Hsun TZU-PIN LU ERIC YAO-YU CHUANG |
關鍵字: | Beagle5.1; Genotype imputation; IMPUTE2; IMPUTE5; Taiwan biobank; Web-server | 公開日期: | 10-六月-2023 | 卷: | 143 | 來源出版物: | Journal of biomedical informatics | 摘要: | Genotype imputation is a commonly used technique that infers un-typed variants into a study's genotype data, allowing better identification of causal variants in disease studies. However, due to overrepresentation of Caucasian studies, there's a lack of understanding of genetic basis of health-outcomes in other ethnic populations. Therefore, facilitating imputation of missing key-predictor-variants that can potentially improve a risk health-outcome prediction model, specifically for Asian ancestry, is of utmost relevance. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/633295 | ISSN: | 15320464 | DOI: | 10.1016/j.jbi.2023.104423 |
顯示於: | 生理學科所 |
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