https://scholars.lib.ntu.edu.tw/handle/123456789/633366
標題: | A Biomimicking and Multiarm Self-Indicating Nanoassembly for Site-Specific Photothermal-Potentiated Thrombolysis Assessed in Microfluidic and In Vivo Models | 作者: | Liu, Kuan Ting Quiñones, Edgar Daniel Liu, Ming Hsin Lin, Che Wei Chen, Yan Ting Chiang, Chia Che KEVIN CHIA-WEN WU Fan, Yu Jui Chuang, Er Yuan JIASHING YU |
關鍵字: | animal use alternatives (3Rs) | nanoparticles | photothermal thrombolytics | thrombosis therapy | thrombosis vessels-on-a-chip | 公開日期: | 1-一月-2023 | 來源出版物: | Advanced Healthcare Materials | 摘要: | Thrombolytic and antithrombotic therapies are limited by short circulation time and the risk of off-target hemorrhage. Integrating a thrombus-homing strategy with photothermal therapy are proposed to address these limitations. Using glycol chitosan, polypyrrole, iron oxide and heparin, biomimicking GCPIH nanoparticles are developed for targeted thrombus delivery and thrombolysis. The nanoassembly achieves precise delivery of polypyrrole, exhibiting biocompatibility, selective accumulation at multiple thrombus sites, and enhanced thrombolysis through photothermal activation. To simulate targeted thrombolysis, a microfluidic model predicting thrombolysis dynamics in realistic pathological scenarios is designed. Human blood assessments validate the precise homing of GCPIH nanoparticles to activated thrombus microenvironments. Efficient near-infrared phototherapeutic effects are demonstrated at thrombus lesions under physiological flow conditions ex vivo. The combined investigations provide compelling evidence supporting the potential of GCPIH nanoparticles for effective thrombus therapy. The microfluidic model also offers a platform for advanced thrombolytic nanomedicine development. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/633366 | ISSN: | 21922640 | DOI: | 10.1002/adhm.202300682 |
顯示於: | 化學工程學系 |
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