https://scholars.lib.ntu.edu.tw/handle/123456789/633525
標題: | Glutamine and its antioxidative potentials in diabetes | 作者: | Yeh, Sung Ling Shih, Yao Ming MING-TSAN LIN |
關鍵字: | Diabetes | Glutamine | Glutathione | Heat shock protein | Insulin secretion | Oxidative stress | 公開日期: | 1-一月-2020 | 來源出版物: | Diabetes: Oxidative Stress and Dietary Antioxidants | 摘要: | Glutamine (GLN) has many physiological functions in the body. Although it is a nonessential amino acid, GLN is considered as conditionally essential for patients with catabolic conditions. Many studies have demonstrated the benefits of GLN administration on immune functions and suggested that additional GLN supplementation is needed in stressed patients. Diabetes is a catabolic disease with high oxidative stress. Previous studies found that through reducing the production of reactive oxygen species, enhancing insulin secretion, reducing pancreatic β-cell apoptosis, and decreasing the expression of genes associated with pathways that cause diabetic complications, GLN supplementation strongly correlated with better glycemic control in diabetes. In addition, as a precursor of glutathione and also an enhancer of heat shock protein expression, GLN supplementation is associated with increased intracellular antioxidative potential and reduced cellular damage, both of which may play important roles in mitigating tissue injury induced by hyperglycemia. Other mechanistic factors proposed including attenuation of nuclear factor-κB-associated signaling pathways, activation of peroxisome proliferator-activated receptor, and modulation of receptor-mediated apoptosis may also contribute to the benefits of GLN supplementation in diabetes. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/633525 | ISBN: | 9780128157763 | DOI: | 10.1016/B978-0-12-815776-3.00025-5 |
顯示於: | 醫學系 |
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