https://scholars.lib.ntu.edu.tw/handle/123456789/633602
標題: | Topoisomerase I Inhibition Radiosensitizing Hepatocellular Carcinoma by RNF144A-mediated DNA-PKcs Ubiquitination and Natural Killer Cell Cytotoxicity | 作者: | CHIAO-LING TSAI Yang, Po-Sheng FENG-MING HSU ANN-LII CHENG Yu, Wan-Ni CHIA-HSIEN CHENG |
關鍵字: | DNA topoisomerase I; Hepatocellular carcinoma; Lipotecan; RNF144A; Radiotherapy | 公開日期: | 28-六月-2023 | 卷: | 11 | 期: | 3 | 來源出版物: | Journal of clinical and translational hepatology | 摘要: | Topoisomerase I (TOP1) participates the repair of DNA double-strand breaks (DSBs) upon radiation therapy (RT). RNF144A mediates ubiquitination of catalytic subunit of DNA protein kinase (DNA-PKcs), a critical factor in DSB repair. This study aimed to investigate the natural killer (NK) cell-mediated radiosensitization with TOP1 inhibition and the mechanism by DNA-PKcs/RNF144A. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/633602 | ISSN: | 22250719 | DOI: | 10.14218/JCTH.2022.00271 |
顯示於: | 腫瘤醫學研究所 |
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