https://scholars.lib.ntu.edu.tw/handle/123456789/633841
標題: | The proteomic landscape of soft tissue sarcomas | 作者: | Burns, Jessica Wilding, Christopher P Krasny, Lukas Zhu, Xixuan Chadha, Madhumeeta Tam, Yuen Bun Ps, Hari Mahalingam, Aswanth H Lee, Alexander T J Arthur, Amani Guljar, Nafia Perkins, Emma Pankova, Valeriya Jenks, Andrew Djabatey, Vanessa Szecsei, Cornelia McCarthy, Frank Ragulan, Chanthirika Milighetti, Martina Roumeliotis, Theodoros I Crosier, Stephen Finetti, Martina Choudhary, Jyoti S Judson, Ian Fisher, Cyril Schuster, Eugene F Sadanandam, Anguraj WEI-WU CHEN Williamson, Daniel Thway, Khin Jones, Robin L Cheang, Maggie C U Huang, Paul H |
公開日期: | 29-六月-2023 | 卷: | 14 | 期: | 1 | 來源出版物: | Nature communications | 摘要: | Soft tissue sarcomas (STS) are rare and diverse mesenchymal cancers with limited treatment options. Here we undertake comprehensive proteomic profiling of tumour specimens from 321 STS patients representing 11 histological subtypes. Within leiomyosarcomas, we identify three proteomic subtypes with distinct myogenesis and immune features, anatomical site distribution and survival outcomes. Characterisation of undifferentiated pleomorphic sarcomas and dedifferentiated liposarcomas with low infiltrating CD3 + T-lymphocyte levels nominates the complement cascade as a candidate immunotherapeutic target. Comparative analysis of proteomic and transcriptomic profiles highlights the proteomic-specific features for optimal risk stratification in angiosarcomas. Finally, we define functional signatures termed Sarcoma Proteomic Modules which transcend histological subtype classification and show that a vesicle transport protein signature is an independent prognostic factor for distant metastasis. Our study highlights the utility of proteomics for identifying molecular subgroups with implications for risk stratification and therapy selection and provides a rich resource for future sarcoma research. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/633841 | ISSN: | 2041-1723 | DOI: | 10.1038/s41467-023-39486-2 |
顯示於: | 腫瘤醫學研究所 |
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