https://scholars.lib.ntu.edu.tw/handle/123456789/633860
標題: | Impact of BRCA Mutation on the Survival and Risk of Contralateral Breast Cancer in Asian Breast Cancer Patients | 作者: | Lin, Po-Han Chen, Shin-Cheh Tseng, Ling-Ming KING-JEN CHANG Huang, Ai-Chu Cheng, Kuo-Chih Yang, Karen et al., |
關鍵字: | Asian women;BRCA1;BRCA2;Contralateral breast cancer;Survival | 公開日期: | 3-九月-2021 | 來源出版物: | ResearchSquare | 摘要: | Purpose Breast cancer is increasing around the globe, including Asia. We aimed to examine the survival and risk of contralateral breast cancer (CBC) in Asian breast cancer patients with BRCA mutations. Methods A total of 128 breast cancer patients with germline BRCA mutations and 4,754 control breast cancer patients were enrolled. Data on clinical pathologic characteristics, survival and CBC were collected from the medical record. The rates of survival and CBC were estimated by Kaplan-Meier method. Results The mean age of onset in BRCA mutation carriers was significantly younger than control patients (BRCA vs. Non-BRCA: 43.9 vs. 53.2 years-old). BRCA mutation carriers had a higher proportion of triple-negative breast cancer (TNBC) (52%) than control patients (12%, p[removed] |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/633860 | DOI: | 10.21203/rs.3.rs-295032 |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。