https://scholars.lib.ntu.edu.tw/handle/123456789/634024
標題: | Changes of ECG parameters after BNT162b2 vaccine in the senior high school students | 作者: | SHUENN-NAN CHIU YIH-SHARNG CHEN Hsu, Chia-Chen Hua, Yu-Chuan WEI-CHIEH TSENG CHUN-WEI LU MING-TAI LIN CHUN-AN CHEN MEI-HWAN WU YU-TING CHEN Chien, Ting-Chou Hung Tseng, Chien-Lun JOU-KOU WANG |
關鍵字: | arrhythmia;BNT162b2 vaccine;ECG;myocarditis;screening | 公開日期: | 28-十月-2022 | 來源出版物: | ResearchSquare | 摘要: | Purpose: To determine the ECG parameters change and the efficacy of ECG screening for cardiac adverse effect after the second dose of BNT162b2 vaccine in young population. Methods: In December 2021, in cooperation with the school vaccination system of Taipei City government, we performed a ECG screening study during the second dose of BNT162b2 vaccines. Serial comparisons of ECGs and questionnaires survey were performed before and after vaccine in four male-predominant senior high schools. Results: Among 7934 eligible students, 4928 (62.1%) were included in the study. The male/female ratio was 4576/352. In total, 763 students (17.1%) had at least one cardiac symptom after the second vaccine dose, mostly chest pain and palpitations. The depolarization and repolarization parameters (QRS duration and QT interval) decreased significantly after the vaccine with increasing heart rate. Abnormal ECGs were obtained in 51 (1.0%) of the students, of which 1 was diagnosed with mild myocarditis and another 4 were judged to have significant arrhythmia. None of the patients needed to be admitted to hospital and all of these symptoms improved spontaneously. Using these five students as a positive outcome, the sensitivity and specificity of this screening method were 100% and 99.1%, respectively. Conclusions: Cardiac symptoms are common after the second dose of BNT162b2 vaccine, but the incidences of significant arrhythmias and myocarditis are only 0.1%. The serial ECG screening method has high sensitivity and specificity for significant cardiac adverse effect but cost effect needs further discussed. © 2022, CC BY. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/634024 | DOI: | 10.21203/rs.3.rs-2198233/v1 |
顯示於: | 醫學系 |
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