https://scholars.lib.ntu.edu.tw/handle/123456789/634335
標題: | Stereotactic radiosurgery for medium and large uveal melanoma with a non-invasive eye immobilization device, a single institutional case series | 作者: | Tsui, Mei Chi Chia-Hsien Cheng, Jason CHANG-PING LIN |
關鍵字: | CyberKnife | Stereotactic radiosurgery | Uveal melanoma | Visual acuity | 公開日期: | 1-一月-2023 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Purpose: To investigate the treatment outcome, visual outcome, and adverse effects of five-fraction stereotactic radiosurgery (SRS) to medium- and large-sized uveal melanoma with a non-invasive eye immobilization device. Methods: Medical records of 14 patients with uveal melanoma receiving SRS with a total dose of 50 Gy in five fractions from 2008 to 2017 were retrospectively reviewed. A non-invasive eye fixation device was used to achieve and monitor eye immobilization. Results: Local tumor control rates were 85.7% and 75.0% at 2 and 5 years, respectively. The average tumor diameter decreased significantly from 10.0 ± 3.21 mm to 8.36 ± 3.71 mm (p = 0.038) 15 months after SRS, while the average tumor thickness decreased significantly from 5.45 ± 2.21 mm to 4.34 ± 2.29 (p = 0.036) 21 months after SRS. The 5-year metastasis-free survival was 87.5%. The mean best-corrected visual acuity (BCVA) deteriorated from logMAR 0.296 at baseline to logMAR 1.112 at the last individual follow-up visits (p < 0.001). Adverse effects of SRS were comparable to those reported with proton-beam radiotherapy or Gamma knife therapy. Conclusion: SRS combined with a non-invasive eye immobilization device is an effective and safe alternative eye-preserving treatment for medium- to large-sized uveal melanoma. BCVA at 3 months may be a predictor for BCVA at 1 year. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/634335 | ISSN: | 09296646 | DOI: | 10.1016/j.jfma.2023.04.013 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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