https://scholars.lib.ntu.edu.tw/handle/123456789/634477
標題: | Novel polypeptide composite fibrous scaffold with internal chemical boundary | 作者: | Yang, Shao Jiun Yu, Tzu Yi JIASHING YU Huang, Yu Ching Lin, Meng Fang WEI-FANG SU |
關鍵字: | 3D scaffolds | Cell migration | Chemical boundary | Polypeptide | Surface modification | 公開日期: | 1-八月-2023 | 卷: | 30 | 期: | 8 | 來源出版物: | Journal of Polymer Research | 摘要: | Cell migration determines the complete development of mammalian tissue and other pathological phenomena. To investigate the effect of chemical stimuli on such behavior, cells are triggered to translate by the concentration gradient of different molecules on 2D substrates in vitro. But to date unfortunately the polymeric scaffolds for cell migration in 3D environment with chemical stimuli have not been proposed and developed yet. Herein, a novel 3D composite scaffold with an internal chemical boundary is fabricated by electrospinning and mask-assisted electrospray so that the deposition of PBG-N3 particles is confined at specific area initially. The chemical boundary is subsequently formed after selective surface modification of the particles via click reaction. Using a fluorescent alkyne, the boundary of modified regions is clearly observed by fluorescence microscope. This innovative bio-material has the potential to serve as a promising scaffold for investigating the effect of chemical stimuli on cell migration and growth in 3D environment and further on to the application in tissue engineering. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/634477 | ISSN: | 10229760 | DOI: | 10.1007/s10965-023-03695-6 |
顯示於: | 化學工程學系 |
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