https://scholars.lib.ntu.edu.tw/handle/123456789/634687
標題: | The role of noncoding RNAs in Parkinson's disease: biomarkers and associations with pathogenic pathways | 作者: | MING-CHE KUO Liu, Sam Chi-Hao Hsu, Ya-Fang RUEY-MEEI WU |
關鍵字: | Biomarker; Circular RNA/circRNA; Long noncoding RNA/lncRNA; MicroRNA/miRNA; Noncoding RNA; PIWI-interacting RNA/piRNA; Parkinson’s disease; RNA sequencing | 公開日期: | 18-十一月-2021 | 卷: | 28 | 期: | 1 | 起(迄)頁: | 78 | 來源出版物: | Journal of biomedical science | 摘要: | The discovery of various noncoding RNAs (ncRNAs) and their biological implications is a growing area in cell biology. Increasing evidence has revealed canonical and noncanonical functions of long and small ncRNAs, including microRNAs, long ncRNAs (lncRNAs), circular RNAs, PIWI-interacting RNAs, and tRNA-derived fragments. These ncRNAs have the ability to regulate gene expression and modify metabolic pathways. Thus, they may have important roles as diagnostic biomarkers or therapeutic targets in various diseases, including neurodegenerative disorders, especially Parkinson's disease. Recently, through diverse sequencing technologies and a wide variety of bioinformatic analytical tools, such as reverse transcriptase quantitative PCR, microarrays, next-generation sequencing and long-read sequencing, numerous ncRNAs have been shown to be associated with neurodegenerative disorders, including Parkinson's disease. In this review article, we will first introduce the biogenesis of different ncRNAs, including microRNAs, PIWI-interacting RNAs, circular RNAs, long noncoding RNAs, and tRNA-derived fragments. The pros and cons of the detection platforms of ncRNAs and the reproducibility of bioinformatic analytical tools will be discussed in the second part. Finally, the recent discovery of numerous PD-associated ncRNAs and their association with the diagnosis and pathophysiology of PD are reviewed, and microRNAs and long ncRNAs that are transported by exosomes in biofluids are particularly emphasized. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/634687 | ISSN: | 10217770 | DOI: | 10.1186/s12929-021-00775-x |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。