https://scholars.lib.ntu.edu.tw/handle/123456789/635052
標題: | Omadacycline pharmacokinetics/pharmacodynamics in the hollow fiber model and clinical validation of efficacy to treat pulmonary Mycobacterium abscessus disease | 作者: | Singh, Sanjay JANN-YUAN WANG Heysell, Scott K McShane, Pamela J Wadle, Carly Shankar, Prem Huang, Hung-Ling Pasipanodya, Jotam Boorgula, Gunavanthi D Philley, Julie V Gumbo, Tawanda Srivastava, Shashikant |
關鍵字: | Efficacy; Hollow fiber system model; M. abscessus; Pharmacokinetics/pharmacodynamics; Safety | 公開日期: | 七月-2023 | 卷: | 62 | 期: | 1 | 來源出版物: | International journal of antimicrobial agents | 摘要: | Guideline-based therapy (GBT) for pulmonary Mycobacterium abscessus (Mab) disease achieves sustained sputum culture conversion (SSCC) rates of 30%; this is reflected by poor efficacy of GBT in the hollow fiber system model of Mab (HFS-Mab), which killed ∼1.22 log10 CFU/mL. This study was performed to determine which clinical dose of omadacycline, a tetracycline antibiotic, should be used in combination therapy to treat pulmonary Mab disease for relapse-free cure. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/635052 | ISSN: | 09248579 | DOI: | 10.1016/j.ijantimicag.2023.106847 |
顯示於: | 醫學系 |
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