https://scholars.lib.ntu.edu.tw/handle/123456789/635088
標題: | The clinical efficacy of cefoperazone-sulbactam versus piperacillin-tazobactam in the treatment of severe community-acquired pneumonia | 作者: | Lai, Chih-Cheng Chen, Wei-Chih Kuo, Li-Kuo Wang, Yao-Tung Fu, Pin-Kuei SHIH-CHI KU Fang, Wen-Feng Chen, Chin-Ming Tu, Chih-Yen Cheng, Wen-Chien Chen, Chia-Hung |
關鍵字: | acquired pneumonia | cefoperazone | piperacillin | severe community | sulbactam | tazobactam | 公開日期: | 14-七月-2023 | 卷: | 102 | 期: | 28 | 來源出版物: | Medicine | 摘要: | The objective was to compare the clinical efficacy of cefoperazone-sulbactam with piperacillin-tazobactam in the treatment of severe community-acquired pneumonia (SCAP). The retrospective study was conducted from March 1, 2018 to May 30, 2019. Clinical outcomes were compared for patients who received either cefoperazone-sulbactam or piperacillin-tazobactam in the treatment of SCAP. A total of 815 SCAP patients were enrolled. Among them, 343 received cefoperazone-sulbactam, and 472 received piperacillin-tazobactam. Patients who received cefoperazone-sulbactam presented with higher Charlson Comorbidity Index scores. (6.20 ± 2.77 vs 5.72 ± 2.61; P = .009). The clinical cure rates and effectiveness for patients receiving cefoperazone-sulbactam and piperacillin-tazobactam were 84.2% versus 80.3% (P = .367) and 85.4% versus 83.3% (P = .258), respectively. In addition, the overall mortality rate of the cefoperazone-sulbactam group was 16% (n = 55), which was also comparable to the piperacillin-tazobactam group (17.8%, n = 84, P = .572). The primary clinical outcomes for patients receiving cefoperazone-sulbactam were superior compared to those receiving piperacillin-tazobactam after adjusting disease severity status. The clinical efficacy of cefoperazone-sulbactam in the treatment of adult patients with SCAP is comparable to that of piperacillin-tazobactam. After adjusting for disease severity, cefoperazone-sulbactam tended to be superior to piperacillin-tazobactam. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/635088 | ISSN: | 00257974 | DOI: | 10.1097/MD.0000000000034284 |
顯示於: | 醫學系 |
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